Deep-learning language models have shown promise in various biotechnological applications,
including protein design and engineering. Here we describe ProGen, a language model …

As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal
proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid mediators, …

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450 (CYP)
epoxygenases have beneficial effects in certain cardiovascular and kidney diseases. …

Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates
tumor cell debris that may stimulate inflammation and tumor growth. Thus, conventional cancer …

Endogenously produced lipid autacoids are locally acting small molecule mediators that
play a central role in the regulation of inflammation and tissue homeostasis. A well-studied …

Background Acute mountain sickness (AMS) is a usually self-limiting syndrome encompassing
headache, nausea and dizziness. AMS is seen in those that go from low to high altitudes …

Inflammation and angiogenesis in the tumor microenvironment are increasingly implicated
in tumorigenesis. Endogenously produced lipid autacoids, locally acting small-molecule …

Objectives : The aim of this study was to determine whether Libman-Sacks endocarditis is a
pathogenic factor for cerebrovascular disease (CVD) in systemic lupus erythematosus (SLE). …

The majority of biological turnover of lignocellulosic biomass in nature is conducted by fungi,
which commonly use Family 1 carbohydrate-binding modules (CBMs) for targeting …