Pain mechanisms in osteoarthritis: understanding the role of central pain and current approaches to its treatment
PJ Mease, S Hanna, EP Frakes… - The Journal of …, 2011 - jrheum.org
In this literature review, the mechanisms underlying pain associated with osteoarthritis (OA)
are discussed, along with evidence for the efficacy of medications thought to act centrally to …
are discussed, along with evidence for the efficacy of medications thought to act centrally to …
Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation
BT Aldrich, EP Frakes, J Kasuya, DL Hammond… - Neuroscience, 2009 - Elsevier
Chronic neuropathic pain caused by peripheral nerve injury is associated with global
changes in gene expression in damaged neurons. To understand the molecular mechanisms …
changes in gene expression in damaged neurons. To understand the molecular mechanisms …
Duloxetine added to oral nonsteroidal anti-inflammatory drugs for treatment of knee pain due to osteoarthritis: results of a randomized, double-blind, placebo …
EP Frakes, RC Risser, TD Ball… - … medical research and …, 2011 - Taylor & Francis
Objective: To determine the efficacy, tolerability, and safety of duloxetine when added to
oral nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) of the …
oral nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis (OA) of the …
[HTML][HTML] Responsiveness of the Intermittent and Constant Osteoarthritis Pain (ICOAP) scale in a trial of duloxetine for treatment of osteoarthritis knee pain
…, PJ Gaynor, DN D'Souza, EP Frakes - Osteoarthritis and …, 2013 - Elsevier
OBJECTIVE: To assess the change in the Intermittent and Constant Osteoarthritis Pain (ICOAP)-scale
scores in patients taking duloxetine or placebo and to characterize the …
scores in patients taking duloxetine or placebo and to characterize the …
[HTML][HTML] Review of efficacy and safety of duloxetine 40 to 60 mg once daily in patients with diabetic peripheral neuropathic pain
V Skljarevski, EP Frakes, D Sagman… - Pain Research and …, 2012 - hindawi.com
We summarize efficacy and safety findings from 4 double-blind, placebo-controlled, 12-week
studies and 1 open-label, uncontrolled, 34-week maintenance-of-effect (MOE) study that …
studies and 1 open-label, uncontrolled, 34-week maintenance-of-effect (MOE) study that …
The risk of bleeding with duloxetine treatment in patients who use nonsteroidal anti-inflammatory drugs (NSAIDs): analysis of placebo-controlled trials and post …
…, Q Zhang, Y Cheng, J Ahl, EP Frakes… - Drug, Healthcare and …, 2013 - Taylor & Francis
Purpose To assess the safety of duloxetine with regards to bleeding-related events in
patients who concomitantly did, versus did not, use nonsteroidal anti-inflammatory drugs (NSAIDs), …
patients who concomitantly did, versus did not, use nonsteroidal anti-inflammatory drugs (NSAIDs), …
ASSESSMENT OF PATIENT-REPORTED PAIN RELIEF IN TREATED ENDOMETRIOSIS PATIENTS: FINDINGS FROM A REAL-WORLD STUDY IN THE UNITED …
E Surrey, Y Xu, EP Frakes, M Scott, L Lee, J Piercy… - Fertility and …, 2022 - fertstert.org
Objective To assess patient-reported pain relief in endometriosis (EM) for women receiving
Elagolix (ELX), an oral gonadotrophin-releasing hormone (GnRH) antagonist, versus other …
Elagolix (ELX), an oral gonadotrophin-releasing hormone (GnRH) antagonist, versus other …
Development of a scoring system to predict mortality from upper gastrointestinal bleeding
…, RS Sandler, DR Wood, SL Levinson, JT Frakes… - The American journal of …, 1987 - Elsevier
… episode occurred during hospitalization. One hundred seventy-four bleeding episodes in
153 … of bleeding (in hours), number of previous episodes of bleeding; (3) history of GI disease-…
153 … of bleeding (in hours), number of previous episodes of bleeding; (3) history of GI disease-…
[HTML][HTML] Feasibility and safety of prone position transport for severe hypoxemic respiratory failure due to coronavirus disease 2019
RR Seethala, MA Frakes, MN Cocchi… - Critical care …, 2020 - journals.lww.com
… Fourteen patients (56%) had hypotension with at least one episode of mean arterial pressure
less than 65 mm Hg en route, and seven (28%) had an episode of oxygen desaturation …
less than 65 mm Hg en route, and seven (28%) had an episode of oxygen desaturation …
Outcomes of acute esophageal food impaction: success of the push technique
JJ Vicari, JF Johanson, JT Frakes - Gastrointestinal endoscopy, 2001 - Elsevier
… Of these, 29 (47%) returned with a second episode of AEFI, 12 of whom had a Schatzki's …
time of esophageal food disimpaction returned with a second episode of AEFI (p < 0.0001). Of …
time of esophageal food disimpaction returned with a second episode of AEFI (p < 0.0001). Of …