Human Leukocyte Antigen-G5 Secretion by Human Mesenchymal Stem Cells Is Required to Suppress T Lymphocyte and Natural Killer Function and to Induce CD4+CD25high …

…, P Tiberghien, N Rouas-Freiss, ED Carosella… - Stem …, 2008 - academic.oup.com
Adult bone marrow-derived mesenchymal stem cells (MSCs) are multipotent cells that are
the subject of intense investigation in regenerative medicine. In addition, MSCs possess …

Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis

…, C Menier, J Dausset, ED Carosella - Proceedings of the …, 1997 - National Acad Sciences
HLA-G is a nonclassical major histocompatibility complex class I molecule selectively expressed
on cytotrophoblasts at the feto–maternal interface, where it may play an important role …

HLA-G expression in melanoma: a way for tumor cells to escape from immunosurveillance

…, J Dausset, JG Guillet, ED Carosella - Proceedings of the …, 1998 - National Acad Sciences
Considering the well established role of nonclassical HLA-G class I molecules in inhibiting
natural killer (NK) cell function, the consequence of abnormal HLA-G expression in malignant …

HLA-G: from biology to clinical benefits

ED Carosella, P Moreau, J LeMaoult… - Trends in …, 2008 - cell.com
The relevance of the nonclassical human leukocyte antigen (HLA) class I molecule HLA-G in
human physiological and pathological contexts has been the center of intense investigation…

IL-10 selectively induces HLA-G expression in human trophoblasts and monocytes

…, L Gourand, J Dausset, ED Carosella… - International …, 1999 - academic.oup.com
HLA-G plays an essential role in feto-maternal tolerance by inhibiting lysis by maternal NK
cells. The factors that allow tissue-specific activation of HLA-G gene expression in …

The 14 bp deletion-insertion polymorphism in the 3′ UT region of the HLA-G gene influences HLA-G mRNA stability

…, M Le Discorde, G Mouillot, C Marcou, ED Carosella… - Human immunology, 2003 - Elsevier
Human leukocyte antigen (HLA)-G molecules are generated by an alternative splicing of the
primary transcript of the gene and display specialized function in regulating the immune …

HLA-G molecules: from maternal-fetal tolerance to tissue acceptance

ED Carosella, P Moreau, J Le Maoult… - Advances in …, 2003 - books.google.com
Over the past few years, HLA-G, the non-classical HLA class I molecule, has been the center
of investigations that have led to the description of its specific structural and functional …

The α1 domain of HLA-G1 and HLA-G2 inhibits cytotoxicity induced by natural killer cells: Is HLA-G the public ligand for natural killer cell inhibitory receptors?

…, J Dausset, ED Carosella - Proceedings of the …, 1997 - National Acad Sciences
We have investigated the protective role of the membrane-bound HLA-G1 and HLA-G2
isoforms against natural killer (NK) cell cytotoxicity. For this purpose, HLA-G1 and HLA-G2 …

HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Beyond the increasing complexity of the immunomodulatory HLA-G molecule

ED Carosella, B Favier, N Rouas-Freiss… - Blood, The Journal …, 2008 - ashpublications.org
Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC)
class I molecule that functions as an immunomodulatory molecule capable of protecting …