User profiles for E R de Kloet

ER de Kloet

Academy professor & em. Professor of Medical Pharmacology, Leiden University
Verified email at lacdr.leidenuniv.nl
Cited by 79831

Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation

J Reul, ERDE Kloet - Endocrinology, 1985 - academic.oup.com
ER DE KLOET ER DE KLOET … JMHM REUL, ER DE KLOET, Two Receptor Systems
for Corticosterone in Rat Brain: Microdistribution and Differential Occupation, Endocrinology, …

Stress and the brain: from adaptation to disease

ER De Kloet, M Joëls, F Holsboer - Nature reviews neuroscience, 2005 - nature.com
In response to stress, the brain activates several neuropeptide-secreting systems. This eventually
leads to the release of adrenal corticosteroid hormones, which subsequently feed back …

Brain corticosteroid receptor balance in health and disease

ER De Kloet, E Vreugdenhil, MS Oitzl… - Endocrine …, 1998 - academic.oup.com
… Ronald de Kloet , … Ronald de Kloet … Address reprint requests to: ER de Kloet, Ph.D.,
Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research, PO Box …

Stress and cognition: are corticosteroids good or bad guys?

ER De Kloet, MS Oitzl, M Joëls - Trends in neurosciences, 1999 - cell.com
Corticosteroid hormones secreted by the adrenal cortex protect the brain against adverse
events and are essential for cognitive performance. However, in recent literature, the central …

Adrenal steroid receptors and actions in the nervous system

BS McEwen, ER De Kloet… - Physiological …, 1986 - journals.physiology.org
Glucocorticoid hormones have widespread effects within the body, and it has recently been
suggested that many of these effects have in common the protection of the organism from its …

Localisation of 11β-hydroxysteroid dehydrogenase—tissue specific protector of the mineralocorticoid receptor

CRW Edwards, D Burt, MA McIntyre, ER De Kloet… - The Lancet, 1988 - Elsevier
… McEwan BS, de Kloet ER, Rostene WH. Adrenal steroid … de Kloet ER, Reul JMHM. Feedback
action and tonic influence … Sutanto W, van Eckelen AM, Reul JMHH, de Kloet ER. Species-…

Selective corticosteroid antagonists modulate specific aspects of spatial orientation learning.

MS Oitzl, ER De Kloet - Behavioral neuroscience, 1992 - psycnet.apa.org
de Kloet, 1991). There are some indications for the involvement of GR-mediated effects in
processes of memory formation, but the role of hippocampal MRs remains unclear (for reviews …

Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to …

…, G Ramakers, MJ Meaney, ER De Kloet… - Journal of …, 2008 - Soc Neuroscience
Maternal licking and grooming (LG) in infancy influences stress responsiveness and cognitive
performance in the offspring. We examined the effects of variation in the frequency of pup …

Feedback action and tonic influence of corticosteroids on brain function: a concept arising from the heterogeneity of brain receptor systems

ER De Kloet, J Reul - Psychoneuroendocrinology, 1987 - Elsevier
Two types of corticosteroid receptors can be distinguished in rat brain. The type 1 receptor
resembles the kidney mineralocorticoid receptor and has two functional expressions in brain, …

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome

…, RC Bagot, KJ Parker, CH Vinkers, ER de Kloet - …, 2013 - Elsevier
Stressful experiences during early-life can modulate the genetic programming of specific
brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful …