This complete and authoritative presentation of the current status of control theory offers a
useful foundation for both study and research. With emphasis on general nonlinear differential …

Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …

Objective To see whether the distribution patterns of phosphorylated 43kDa TAR DNA‐binding
protein (pTDP‐43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit …

Recent advances in spatially resolved transcriptomics (SRT) technologies have enabled
comprehensive characterization of gene expression patterns in the context of tissue …

Background Tofacitinib (CP-690,550) is a novel oral Janus kinase inhibitor that is being
investigated for the treatment of rheumatoid arthritis. Methods In this 12-month, phase 3 trial, 717 …

Background Methotrexate is the most frequently used first-line antirheumatic drug. We report
the findings of a phase 3 study of monotherapy with tofacitinib, an oral Janus kinase inhibitor…

RNA-binding proteins, and in particular TAR DNA-binding protein 43 (TDP43), are central to
the pathogenesis of motor neuron diseases and related neurodegenerative disorders. …

This study investigated the reliability and stability of an autism diagnosis in children under 3
years of age who received independent diagnostic evaluations from two clinicians during …

Behçet's disease is a chronic systemic inflammatory disorder characterized by four major
manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions 1 . We …

Accumulation of hyperphosphorylated, ubiquitinated and N-terminally truncated TAR DNA-binding
protein (TDP-43) is the pathological hallmark lesion in most familial and sporadic …