Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme
GN Smith Jr, EA Mickler, KA Hasty… - Arthritis & Rheumatism …, 1999 - Wiley Online Library
Objective To investigate the inhibition of matrix metalloproteinase 1 (MMP‐1), MMP‐8, and
MMP‐13 by doxycycline, and to determine whether the variable hemopexin‐like domain of …
MMP‐13 by doxycycline, and to determine whether the variable hemopexin‐like domain of …
[HTML][HTML] Neutralizing IL-17 prevents obliterative bronchiolitis in murine orthotopic lung transplantation
L Fan, HL Benson, R Vittal, EA Mickler… - American journal of …, 2011 - Elsevier
Obliterative bronchiolitis (OB) is the key impediment to the long-term survival of lung
transplant recipients and the lack of a robust preclinical model precludes examining OB …
transplant recipients and the lack of a robust preclinical model precludes examining OB …
[HTML][HTML] Crosstalk between TGF-β1 and complement activation augments epithelial injury in pulmonary fibrosis
H Gu, EA Mickler, OW Cummings… - The FASEB …, 2014 - ncbi.nlm.nih.gov
The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46
and CD55) regulate circulating immune complex–mediated complement activation in …
and CD55) regulate circulating immune complex–mediated complement activation in …
Systems analysis of the human pulmonary arterial hypertension lung transcriptome
Pulmonary arterial hypertension (PAH) is characterized by increased pulmonary artery
pressure and vascular resistance, typically leading to right heart failure and death. Current …
pressure and vascular resistance, typically leading to right heart failure and death. Current …
Diacerhein treatment reduces the severity of osteoarthritis in the canine cruciate‐deficiency model of osteoarthritis
…, SL Myers, KD Brandt, EA Mickler… - … : Official Journal of …, 1999 - Wiley Online Library
… MICKLER, and MARJORIE E. ALBRECHT … Smith GN Jr, Myers SL, Brandt KD, Mickler
EA. Effect of intraarticular hyaluronan injection in experimental canine osteoarthritis. Arthritis …
EA. Effect of intraarticular hyaluronan injection in experimental canine osteoarthritis. Arthritis …
IL-17 induces type V collagen overexpression and EMT via TGF-β-dependent pathways in obliterative bronchiolitis
…, L Fan, DS Greenspan, EA Mickler… - … of Physiology-Lung …, 2013 - journals.physiology.org
Obliterative bronchiolitis (OB), a fibrotic airway lesion, is the leading cause of death after
lung transplantation. Type V collagen [col(V)] overexpression and IL-17-mediated anti-col(V) …
lung transplantation. Type V collagen [col(V)] overexpression and IL-17-mediated anti-col(V) …
[HTML][HTML] Type V collagen induced tolerance suppresses collagen deposition, TGF-β and associated transcripts in pulmonary fibrosis
R Vittal, EA Mickler, AJ Fisher, C Zhang, K Rothhaar… - PloS one, 2013 - journals.plos.org
Rationale Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized
by progressive scarring and matrix deposition. Recent reports highlight an autoimmune …
by progressive scarring and matrix deposition. Recent reports highlight an autoimmune …
[HTML][HTML] IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis
E Cipolla, AJ Fisher, H Gu, EA Mickler… - The FASEB …, 2017 - ncbi.nlm.nih.gov
Interleukin 17A (IL-17A) and complement (C′) activation have each been implicated in the
pathogenesis of idiopathic pulmonary fibrosis (IPF). We have reported that IL-17A induces …
pathogenesis of idiopathic pulmonary fibrosis (IPF). We have reported that IL-17A induces …
[HTML][HTML] Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis
H Gu, AJ Fisher, EA Mickler, F Duerson III… - The FASEB …, 2016 - ncbi.nlm.nih.gov
Complement activation, an integral arm of innate immunity, may be the critical link to the
pathogenesis of idiopathic pulmonary fibrosis (IPF). Whereas we have previously reported …
pathogenesis of idiopathic pulmonary fibrosis (IPF). Whereas we have previously reported …
Effect of intraarticular hyaluronan injection in experimental canine osteoarthritis
…, SL Myers, KD Brandt, EA Mickler - Arthritis & Rheumatism …, 1998 - Wiley Online Library
… Rydell N, Balazs EA. Effect of intraarticular injection of hyaluronic acid on the clinical
symptoms of osteoarthritis and on granulation tissue formation. Clin Orthop Re1 Res 1971;8025-32. …
symptoms of osteoarthritis and on granulation tissue formation. Clin Orthop Re1 Res 1971;8025-32. …