OBJECTIVE: To describe the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K),
a modification of SLEDAI to reflect persistent, active disease in those descriptors …

Objective To investigate potential differences between childhood‐onset and adult‐onset
systemic lupus erythematosus (SLE). Methods An inception cohort with childhood‐onset SLE (n …

Objective Because women with systemic lupus erythematosus (SLE) are 5–8 times more
likely to develop coronary heart disease (CHD) than are women in the general population, we …

OBJECTIVE: To determine the pattern of accumulation of damage in an inception cohort of
patients with systemic lupus erythematosus (SLE) followed yearly for at least 15 years, and to …

Objective Survival of patients with systemic lupus erythematosus (SLE) has improved
significantly, but new morbidities have emerged, leading to altered patterns of outcome in this …

OBJECTIVE: To determine prevalence and type of atherosclerotic vascular events (AVE)
occurring after entry to the University of Toronto Lupus Clinic; and to compare risk factors in …

Objective Selection of flare as the primary outcome variable in systemic lupus erythematosus
(SLE) clinical trials fails to capture patients with persistently active disease (PAD). We …

Objective. To evaluate the effect of lupus nephritis on pregnancy with respect to fetal outcome,
maternal complications, and lupus activity. Methods. All pregnancies seen between 1970 …

OBJECTIVE: To develop a measurement of lupus disease activity over time. METHODS: We
studied patients from the University of Toronto Lupus Clinic with "regular" followup, defined …

A prospective outcome analysis was conducted on 100 consecutive women who requested
explanation of their silicone gel breast implants from January 6, 1992 (the moratorium), …