ContextRegular intake of cocoa-containing foods is linked to lower cardiovascular mortality
in observational studies. Short-term interventions of at most 2 weeks indicate that high doses …

Background— For patients undergoing percutaneous coronary intervention, the administration
of a clopidogrel loading dose ranging from 300 to 600 mg is currently recommended. It is …

Background Epidemiological evidence suggests blood pressure–lowering effects of cocoa
and tea. We undertook a meta-analysis of randomized controlled trials to determine changes …

Clinical efficacy of the antiplatelet drug clopidogrel is hampered by its variable biotransformation
into the active metabolite 1 , 2 . The variability in the clinical response to clopidogrel …

Objective The antiplatelet activity of clopidogrel is characterized by considerable
interindividual differences. Variable intestinal absorption is suggested to contribute to the …

Objective To evaluate the accumulated information from genetic association studies
investigating the impact of variants of the cytochrome P450 (CYP) 2C19 genotype on the clinical …

Methods Methods We conducted a randomized crossover trial in 13 otherwise healthy
individuals (6 men and 7 women, aged 55-64 years, with body mass index of 21.9-26.2 […

The adenosine diphosphate (ADP) receptor P2Y12 blocking agent clopidogrel is clinically
proven to be efficient in preventing thrombotic events. However, its therapeutic value is limited …

Ergothioneine is a native membrane-impermeable thiol compound that is specifically
accumulated in cells via the organic cation transporter OCTN1. In humans, OCTN1 and …

High amounts of acrylamide in some foods result in an estimated daily mean intake of 50 μg
for a western style diet. Animal studies have shown the carcinogenicity of acrylamide upon …