… and tile Sharp method modified by van der Heijde, scored by … -trained readers, the van der
Heijde modification showed the … the Sharp method and the van der Heijde modification is the …

Background Neutralization of tumor necrosis factor α (TNF-α) for three to six months reduces
the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to …

An investigation of clinical and laboratory variables which might form the basis for judging
disease activity in clinical practice was made by six rheumatologists in a prospective study of …

The literature on prognostic features on the final outcome in RA is reviewed. It is generally
agreed that female sex and a positive RF are variables indicating a poor prognosis. Long-…

In a prospective followup study of 147 patients with rheumatoid arthritis of recent onset, we
assessed the progression of radiographic evidence of joint damage on films of the patients' …

There is no agreement as to which variable best mirrors disease activity in rheumatoid arthritis
(RA) and no studies have been performed on the validity of disease activity variables. In …

Background The value of intensive combination therapy in early rheumatoid arthritis is
unproven. In a multicentre, double-blind, randomised trial (COBRA), we compared the …

… in van der Heijde modification of the total Sharp score at week 54: 0.4 5.8 and 0.5 5.6 versus
3.7 9.6, respectively; P< 0.001 for each comparison). In addition, physical function improved …

… Two independent assessors scored radiographs in sequence according to the Sharp/van
der Heijde method. Outcomes were analyzed by generalized estimating equations on the …

Agreement on response criteria in rheumatoid arthritis (RA) has allowed better standardization
and interpretation of clinical trial reports. With recent advances in therapy, the proportion …