In this article, the 2010 European League against Rheumatism (EULAR) recommendations
for the management of rheumatoid arthritis (RA) with synthetic and biological disease-…

Treatment of rheumatoid arthritis (RA) may differ among rheumatologists and currently, clear
and consensual international recommendations on RA treatment are not available. In this …

Integrins are αβ heterodimeric receptors that mediate divalent cation-dependent cell-cell and
cell-matrix adhesion through tightly regulated interactions with ligands. We have solved the …

… MD David L Scott David L Scott … , poor, or very poor; C-reactive protein (CRP) 20 mg/L or
higher (normal less than 10 mg/L); or erythrocyte sedimentation rate (ESR) 28 mm/h or higher. …

A chemical description of the action of phospholipase A 2 (PLA 2 ) can now be inferred with
confidence from three high-resolution x-ray crystal structures. The first is the structure of the …

OBJECTIVE Muscles are essential components of our sensorimotor system that help maintain
balance and perform a smooth gait, but it is unclear whether arthritic damage adversely …

Objective The assessment of health-related quality-of-life (HRQoL) in rheumatoid arthritis (RA)
is becoming increasingly common in both research and clinical practice. One of the most …

The clinical manifestations of cholera are largely attributable to the actions of a secreted
hexameric AB 5 enterotoxin (choleragen). We have independently solved and refined the three-…

The 2.0 angstroms crystal structure of a complex containing bee-venom phospholipase A 2 (PLA
2 ) and a phosphonate transition-state analogue was solved by multiple isomorphous …

Objective. MTX is widely used to treat synovitis in PsA without supporting trial evidence. The
aim of our study was to test the value of MTX in the first large randomized placebo-…