Objective The 1980 American College of Rheumatology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

Objective. The 1980 American College of Rheuma-tology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

Objective To document disease activity and functional status in patients with scleroderma (systemic
sclerosis [SSc]) and Raynaud's phenomenon (RP) and to determine the sensitivity to …

Objective To examine the efficacy of methotrexate monotherapy relative to etanercept
monotherapy and the value of combining methotrexate and etanercept for the treatment of patients …

Objective To evaluate the efficacy and tolerability of an oral preparation of iloprost, a prostacyclin
analog, in patients with Raynaud's phenomenon (RP) secondary to systemic sclerosis (…

OBJECTIVE: This study compares the responsiveness to change of the Medical Outcomes
Study Short Form Health Survey (SF-36), a measure of health related quality of life (HRQOL), …

Background There are no systemic therapies approved in the United States to treat pediatric
psoriasis. Objective We sought to evaluate long-term safety and efficacy of etanercept in …

Objectives To characterise the comparative effectiveness of combination therapy (a tumour
necrosis factor inhibitor (TNFi) and a conventional synthetic disease-modifying antirheumatic …

Background Growth differentiation factor (GDF)-15 is a secreted member of the transforming
growth factor-β cytokine superfamily. GDF-15 levels are elevated in the serum of patients …

No current theory of the mechanisms involved in the pathophysiology of rheumatoid arthritis
(RA) explains its important clinical features. We hypothesize that neural mechanisms are …