The immunosuppressive function of regulatory B cells has been shown in several murine
models of chronic inflammation, including collagen-induced arthritis, inflammatory bowel …

Objective. Different sets of diagnostic criteria have been proposed for Sjögren's syndrome (SS),
but none have been validated with a large series of patients or in a multicenter study. We …

Regulatory T cells have been clearly implicated in the control of disease in murine models
of autoimmunity. The paucity of data regarding the role of these lymphocytes in human …

Objective B cells are likely to contribute to the pathogenesis of systemic lupus erythematosus
(SLE), and rituximab induces depletion of B cells. The Exploratory Phase II/III SLE …

Objectives To develop recommendations for the management of adult and paediatric lupus
nephritis (LN). Methods The available evidence was systematically reviewed using the …

The relevance of regulatory B cells in the maintenance of tolerance in healthy individuals or
in patients with immune disorders remains understudied. In healthy individuals, CD19 + …

Objective. To test the reliability of the Systemic Lupus International Collaborating Clinics/American
College of Rheumatology (SLICC/ACR) Damage Index and the Systemic Lupus …

Objective To gain preliminary evidence for the safety and efficacy of B lymphocyte depletion
therapy in refractory systemic lupus erythematosus (SLE). Methods Six female patients with …

Objective Several reports have noted an increased incidence of malignant lymphoma in
patients with Sjögren's syndrome (SS). Each case series has consisted of a limited number of …

Background and aims We studied damage accrual and factors determining development
and progression of damage in an international cohort of systemic lupus erythematosus (SLE) …