OBJECTIVE: CF101, an A3 adenosine receptor (A3AR) agonist, is a small orally bioavailable
molecule known to suppress in vitro the production of tumor necrosis factor-alpha (TNF-…

NF-κB and the upstream kinase PKB/Akt are highly expressed in chemoresistance tumor
cells and may hamper the apoptotic pathway. CF101, a specific agonist to the A 3 adenosine …

10.7554/eLife.30918.001 Mature T cells bearing αβ T cell receptors react with foreign
antigens bound to alleles of major histocompatibility complex proteins (MHC) that they were …

The interaction of αβ T-cell antigen receptors (TCRs) with peptides bound to MHC molecules
lies at the center of adaptive immunity. Whether TCRs have evolved to react with MHC or, …

When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly
to T-cell activation in vitro. The greater proportional representation of macrophages in this …

Recent advances in immunotherapy have not addressed the challenge presented by ovarian
cancer. Although the peritoneum is an “accessible” locus for this disease there has been …

High Mφ:T cell ratios suppress the immune response to the retroviral superantigen Mls by
IFNγ-triggered production of the arg- and trp-consuming enzymes iNOS and IDO. Attempts to …

Peritoneal macrophages suppressed T lymphocyte activation by amino acid catabolism.
CTLA-4-Ig complemented this form of suppression by blocking the costimulation of T cells. …

The interaction of α T cell antigen receptors (TCRs) with peptides in the context of major
histocompatibility complex (MHC) molecules lies at the center of adaptive immunity. Whether the …

Mature T cells bearing αβ T cell receptors react with foreign antigens bound to alleles of
major histocompatibility complex proteins (MHC) that they were exposed to during their …