Background Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid
arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF …

OBJECTIVE: To determine the incidence and presenting features of primary and secondary
vasculitides in children across the Czech Republic. METHODS: The population of 2.02 …

Objective To determine the clinical and immunologic features of systemic sclerosis (SSc) in
a large group of children and describe the clinical evolution of the disease and compare it …

OBJECTIVE: To characterize pediatric patients who had been diagnosed with polyarteritis
nodosa (PAN) through necrotizing vasculitis of the small and mid-size arteries or those with …

Objectives This paper aims to describe clinical and laboratory features and disease outcome
in a single-centre cohort of patients with PFAPA syndrome (Periodic Fever, Aphtous …

Objective To evaluate the baseline clinical characteristics of juvenile systemic sclerosis (SSc)
patients in the international juvenile SSc inception cohort, and to compare these …

Objective. To investigate whether methylenetetrahydrofolate reductase (MTHFR) C677T and
A1298C polymorphisms and erythrocyte concentration of methotrexate (EMTX) could serve …

Objective. To develop recommendations for investigation and monitoring of children with
Raynaud’s syndrome, based on paediatric evidence collated by a systematic review. Method. A …

In this research, 558 family timber-frame houses newly built in the period of 2006–2019 in
the Czech Republic were assessed in terms of their airtightness. The air leakage through the …

Objectives Long-term safety and efficacy of adalimumab among patients with juvenile idiopathic
arthritis (JIA) was evaluated through 6 years of treatment. Methods Children aged 4–17 …