User profiles for D. KURNIK

Daniel Kurnik

Clinical Associate Professor, Rambam Health Care Campus and Technion, Israel Institute of …
Verified email at rambam.health.gov.il
Cited by 3538

Warfarin and vitamin K intake in the era of pharmacogenetics

Y Lurie, R Loebstein, D Kurnik… - British journal of …, 2010 - Wiley Online Library
The considerable variability in the warfarin dose–response relationship between individuals,
is explained mainly by genetic variation in its major metabolic (CYP2C9) and target (…

Complex drug-drug-disease interactions between amiodarone, warfarin, and the thyroid gland

D Kurnik, R Loebstein, Z Farfel, D Ezra, H Halkin… - Medicine, 2004 - journals.lww.com
… At 15 weeks, hypothyroidism was severe (see Table 1), and L-thyroxine supplements
were started at 50 μg/d and raised at 21 weeks to 86 μg/d. Thyroid hormone levels gradually …

Integration of genetic, clinical, and INR data to refine warfarin dosing

…, C Eby, J Shin, H Kim, D Kurnik… - Clinical …, 2010 - Wiley Online Library
Well‐characterized genes that affect warfarin metabolism (cytochrome P450 (CYP) 2C9)
and sensitivity (vitamin K epoxide reductase complex 1 (VKORC1)) explain one‐third of the …

Combined genetic profiles of components and regulators of the vitamin K-dependent γ-carboxylation system affect individual sensitivity to warfarin

…, R Loebstein, S Almog, D Kurnik… - Thrombosis and …, 2006 - thieme-connect.com
We examined the influence of combined genotypes on interindividual variability in warfarin
dose-response. In 100 anticoagulated patients we quantified the effects of polymorphisms in: …

[HTML][HTML] Analyzing medical research results based on synthetic data and their relation to real data results: systematic comparison from five observational studies

…, Y Lurie, ZS Azzam, J Khoury, D Kurnik… - JMIR medical …, 2020 - medinform.jmir.org
Background: Privacy restrictions limit access to protected patient-derived health information
for research purposes. Consequently, data anonymization is required to allow researchers …

The association of proton pump inhibitors and hypomagnesemia in the community setting

…, J Lomnicky, D Kurnik - The Journal of …, 2014 - Wiley Online Library
Evidence for the association between hypomagnesemia and proton pump inhibitors (PPIs),
highlighted by the 2011 FDA Drug Safety Communication, rests mainly on studies in …

Bioavailability of oral vs. subcutaneous low‐dose methotrexate in patients with Crohn's disease

D Kurnik, R Loebstein, E Fishbein… - Alimentary …, 2003 - Wiley Online Library
Background : Oral methotrexate and folic acid are partly absorbed by a common intestinal
transporter. Aim : To determine the relative bioavailability of oral low‐dose methotrexate …

[HTML][HTML] Choline transporter gene variation is associated with attention-deficit hyperactivity disorder

…, M Mazei-Robison, A Steele, DM Kurnik… - Journal of …, 2009 - Springer
The neurotransmitter acetylcholine (ACh) plays a critical role in brain circuits mediating motor
control, attention, learning and memory. Cholinergic dysfunction is associated with multiple …

A genetic risk score that includes common type 2 diabetes risk variants is associated with gestational diabetes

…, D Kurnik, SP Collier, D Conway… - Clinical …, 2017 - Wiley Online Library
… in the general population, c GDM variants and d glycaemic trait variants in pregnant women
… (C1431T), that is in weak linkage disequilibrium with rs1801282 (D’=0.68, R 2 =.42) was …

Prescriber response to computerized drug alerts for electronic prescriptions among hospitalized patients

YZ Straichman, D Kurnik, I Matok, H Halkin… - International Journal of …, 2017 - Elsevier
… Author links open overlay panel Yael Zenziper Straichman a f , Daniel Kurnik a d , Ilan Matok
f , Hillel … Daniel Kurnik contributed to study design, data collection, statistical analysis, and …