Manifold learning-based methods for analyzing single-cell RNA-sequencing data
Recent advances in single-cell RNA sequencing technologies enable deep insights into
cellular development, gene regulation, and phenotypic diversity by measuring gene expression …
cellular development, gene regulation, and phenotypic diversity by measuring gene expression …
[HTML][HTML] Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources
Quantitative views of cellular functions require precise measures of rates of biomolecule
production, especially proteins—the direct effectors of biological processes. Here, we present a …
production, especially proteins—the direct effectors of biological processes. Here, we present a …
Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
CB Little, A Barai, D Burkhardt, SM Smith… - … : Official Journal of …, 2009 - Wiley Online Library
… A–D, Maximal (A and B) and summed (C and D) scores for aggrecan loss in femoral and
tibial cartilage of wild-type and MMP-13–knockout mice 4 and 8 weeks after medial meniscal …
tibial cartilage of wild-type and MMP-13–knockout mice 4 and 8 weeks after medial meniscal …
Cellular mechanisms of tumour suppression by the retinoblastoma gene
DL Burkhart, J Sage - Nature Reviews Cancer, 2008 - nature.com
The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad range
of paediatric and adult cancers, and a plethora of cellular functions and partners have been …
of paediatric and adult cancers, and a plethora of cellular functions and partners have been …
Visualizing structure and transitions in high-dimensional biological data
The high-dimensional data created by high-throughput technologies require visualization
tools that reveal data structure and patterns in an intuitive form. We present PHATE, a …
tools that reveal data structure and patterns in an intuitive form. We present PHATE, a …
Pulmonary vein isolation for the treatment of atrial fibrillation in patients with impaired systolic function
…, D Bash, R Schweikert, D Burkhardt… - Journal of the American …, 2004 - jacc.org
Objectives : We aimed to determine the safety and efficacy of pulmonary vein isolation (PVI)
in atrial fibrillation (AF) patients with impaired left ventricular (LV) systolic function. …
in atrial fibrillation (AF) patients with impaired left ventricular (LV) systolic function. …
Endo-epicardial homogenization of the scar versus limited substrate ablation for the treatment of electrical storms in patients with ischemic cardiomyopathy
L Di Biase, P Santangeli, DJ Burkhardt, R Bai… - Journal of the American …, 2012 - jacc.org
Objectives : This study investigated the impact on recurrences of 2 different substrate
approaches for the treatment of these arrhythmias. Background : Catheter ablation of electrical …
approaches for the treatment of these arrhythmias. Background : Catheter ablation of electrical …
The risk of thromboembolism and need for oral anticoagulation after successful atrial fibrillation ablation
…, R Horton, P Mohanty, D Patel, DJ Burkhardt… - Journal of the American …, 2010 - jacc.org
… Burkhardt … Steven D., Rostock T., Lutomsky B.et al. : "What is the real atrial fibrillation burden
after … Burkhardt is a chief medical advisor for Stereotaxis. Dr. Haissaguerre has received …
after … Burkhardt is a chief medical advisor for Stereotaxis. Dr. Haissaguerre has received …
[HTML][HTML] Topographical analysis of the structural, biochemical and dynamic biomechanical properties of cartilage in an ovine model of osteoarthritis
RC Appleyard, D Burkhardt, P Ghosh, R Read… - Osteoarthritis and …, 2003 - Elsevier
Objective The relationship between the topographical variations in the structural, biochemical
and dynamic biomechanical properties of articular cartilage (AC) before and 6 months …
and dynamic biomechanical properties of articular cartilage (AC) before and 6 months …
Mitochondrial phylogenomics of Hemiptera reveals adaptive innovations driving the diversification of true bugs
…, EG Chapman, D Burkhardt… - … of the Royal …, 2017 - royalsocietypublishing.org
Hemiptera, the largest non-holometabolous order of insects, represents approximately 7%
of metazoan diversity. With extraordinary life histories and highly specialized morphological …
of metazoan diversity. With extraordinary life histories and highly specialized morphological …