Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression
…, JL Stein, M Montecino, A Javed, SK Zaidi, DW Young… - Oncogene, 2004 - nature.com
We present an overview of Runx involvement in regulatory mechanisms that are requisite
for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the …
Networks and hubs for the transcriptional control of osteoblastogenesis
We present an overview of the concepts of tissue-specific transcriptional control mechanisms
essential for development of the bone cell phenotype. BMP2 induced transcription factors …
essential for development of the bone cell phenotype. BMP2 induced transcription factors …
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
Y Feng, TJ Mitchison, A Bender, DW Young… - Nature Reviews Drug …, 2009 - nature.com
Multi-parameter phenotypic profiling of small molecules provides important insights into their
mechanisms of action, as well as a systems level understanding of biological pathways and …
mechanisms of action, as well as a systems level understanding of biological pathways and …
[HTML][HTML] Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
JC Chow, DW Young, DT Golenbock, WJ Christ… - Journal of Biological …, 1999 - ASBMB
TLR4 is a member of the recently identified Toll-like receptor family of proteins and has been
putatively identified as Lps, the gene necessary for potent responses to lipopolysaccharide …
putatively identified as Lps, the gene necessary for potent responses to lipopolysaccharide …
[HTML][HTML] The extra domain A of fibronectin activates Toll-like receptor 4
Y Okamura, M Watari, ES Jerud, DW Young… - Journal of Biological …, 2001 - ASBMB
Cellular fibronectin, which contains an alternatively spliced exon encoding type III repeat
extra domain A (EDA), is produced in response to tissue injury. Fragments of fibronectin have …
extra domain A (EDA), is produced in response to tissue injury. Fragments of fibronectin have …
Familial and cultural perceptions and beliefs of oral hygiene and dietary practices among ethnically and socio-economicall diverse groups.
…, C Splieth, TC Soo, H Whelton, DW Young - Community dental …, 2004 - europepmc.org
OBJECTIVE; The aim of this international study was to develop a valid and reliable psychometric
measure to examine the extent to which parents' attitudes about engaging in twice-daily …
measure to examine the extent to which parents' attitudes about engaging in twice-daily …
[HTML][HTML] Integrating high-content screening and ligand-target prediction to identify mechanism of action
DW Young, A Bender, J Hoyt, E McWhinnie… - Nature chemical …, 2008 - nature.com
High-content screening is transforming drug discovery by enabling simultaneous measurement
of multiple features of cellular phenotype that are relevant to therapeutic and toxic …
of multiple features of cellular phenotype that are relevant to therapeutic and toxic …
[HTML][HTML] Cellular events mediated by lipopolysaccharide-stimulated Toll-like receptor 4: MD-2 is required for activation of mitogen-activated protein kinases and Elk-1
H Yang, DW Young, F Gusovsky, JC Chow - Journal of Biological Chemistry, 2000 - ASBMB
Lipopolysaccharide (LPS) stimulates multiple signaling events, including nuclear factor-κB (NF-κB)
activity and the mitogen-activated protein (MAP) kinases, ERK, JNK, and p38 in LPS-…
activity and the mitogen-activated protein (MAP) kinases, ERK, JNK, and p38 in LPS-…
[HTML][HTML] The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts
M Galindo, J Pratap, DW Young… - Journal of Biological …, 2005 - ASBMB
The Runx2 (CBFA1/AML3/PEBP2αA) transcription factor promotes skeletal cell differentiation,
but it also has a novel cell growth regulatory activity in osteoblasts. We addressed here …
but it also has a novel cell growth regulatory activity in osteoblasts. We addressed here …
Route to three-dimensional fragments using diversity-oriented synthesis
…, JA Wilson, PA Clemons, DW Young - Proceedings of the …, 2011 - National Acad Sciences
Fragment-based drug discovery (FBDD) has proven to be an effective means of producing
high-quality chemical ligands as starting points for drug-discovery pursuits. The increasing …
high-quality chemical ligands as starting points for drug-discovery pursuits. The increasing …