The importin α/β heterodimer targets hundreds of proteins to the nuclear-pore complex (NPC)
and facilitates their translocation across the nuclear envelope. Importin α binds to classical …

Adenine phosphoribosyltransferase (APRT) deficiency, cystinuria, Dent disease, familial
hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and primary …

Acetazolamide, a potent carbonic anhydrase (CA) inhibitor, is the most commonly used and
best-studied agent for the amelioration of acute mountain sickness (AMS). The actual …

Purpose : The purpose of this guideline is to provide a clinical framework for the diagnosis,
prevention and follow-up of adult patients with kidney stones based on the best available …

ContextHigh plasma homocysteine levels are a risk factor for mortality and vascular disease
in observational studies of patients with chronic kidney disease. Folic acid and B vitamins …

The nuclear envelope defines a compartment boundary which is penetrated by pores that
mediate a remarkable transport process. Precursor RNAs are retained in the nucleus, while …

… Roberts and DS Goldfarb, unpublished observations). The cell shown in Figure 7A, a–c,
contains two blebs, one of which seems to be filled with granular material from the adjacent …

Translocation through nuclear pore complexes (NPCs) requires interactions between
receptor–cargo complexes and phenylalanine-glycine (FG) repeats in multiple FG domain-…

… with the vacuolar ATPase subunit Vma8p (Roberts and Goldfarb, unpublished results). Thus,
Vac8p … Neither VAB2 norAPG13 are required for NV junction formation (Pan and Goldfarb, …

Mammalian species have co-evolved with intestinal microbial communities that can shape
development and adapt to environmental changes, including antibiotic perturbation or …