Genome-wide association studies have identified hundreds of genetic variants associated
with complex human diseases and traits, and have provided valuable insights into their …

PURPOSE: To develop concise, patient-focussed, up to date, evidence-based, expert
consensus recommendations for the management of hip and knee osteoarthritis (OA), which are …

OBJECTIVE: To update evidence for available therapies in the treatment of hip and knee
osteoarthritis (OA) and to examine whether research evidence has changed from 31 January …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D)
and 38,987 controls of European descent and following up previously unidentified meta-…

Objective To develop concise, up-to-date, patient-focused, evidence-based, expert consensus
guidelines for the management of knee osteoarthritis (OA), intended to inform patients, …

Background The relation between body weight and overall mortality remains controversial
despite considerable investigation. Methods We examined the association between body-…

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

Advanced age-related macular degeneration (AMD) is the leading cause of blindness in the
elderly, with limited therapeutic options. Here we report on a study of >12 million variants, …

Background The effect of adding progestins to estrogen therapy on the risk of breast cancer
in postmenopausal women is controversial. Methods To quantify the relation between the …