[HTML][HTML] Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
…, BB Oliver, JL Su, SS Sundseth, DA Winegar… - Journal of Biological …, 1997 - ASBMB
Accumulation of cholesterol causes both repression of genes controlling cholesterol
biosynthesis and cellular uptake and induction of cholesterol 7α-hydroxylase, which leads to the …
biosynthesis and cellular uptake and induction of cholesterol 7α-hydroxylase, which leads to the …
A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport
…, NL Bodkin, MC Lewis, DA Winegar… - Proceedings of the …, 2001 - National Acad Sciences
The peroxisome proliferator-activated receptors (PPARs) are dietary lipid sensors that
regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs …
regulate fatty acid and carbohydrate metabolism. The hypolipidemic effects of the fibrate drugs …
[HTML][HTML] Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity
…, P Poulain, B Derudas, JM Herbert, DA Winegar… - Journal of Biological …, 2000 - ASBMB
Fibrates and glitazones are two classes of drugs currently used in the treatment of dyslipidemia
and insulin resistance (IR), respectively. Whereas glitazones are insulin sensitizers …
and insulin resistance (IR), respectively. Whereas glitazones are insulin sensitizers …
[HTML][HTML] Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knock-out mice …
…, S Li, JA Houmard, JM Way, DA Winegar… - Journal of Biological …, 2002 - ASBMB
Ablation of peroxisome proliferator activated receptor (PPAR) α, a lipid-activated transcription
factor that regulates expression of β-oxidative genes, results in profound metabolic …
factor that regulates expression of β-oxidative genes, results in profound metabolic …
Baseline data from American society for metabolic and bariatric surgery-designated bariatric surgery centers of excellence using the bariatric outcomes longitudinal …
EJ DeMaria, V Pate, M Warthen, DA Winegar - Surgery for Obesity and …, 2010 - Elsevier
BACKGROUND: The Bariatric Outcomes Longitudinal Database (BOLD) is a registry of self-reported
bariatric surgery patient information from the American Society for Metabolic and …
bariatric surgery patient information from the American Society for Metabolic and …
Risk stratification of serious adverse events after gastric bypass in the Bariatric Outcomes Longitudinal Database
ML Maciejewski, DA Winegar, JF Farley… - Surgery for Obesity and …, 2012 - Elsevier
BACKGROUND: There is now sufficient demand for bariatric surgery to compare bariatric
surgeons and bariatric centers according to their postsurgical outcomes, but few validated risk …
surgeons and bariatric centers according to their postsurgical outcomes, but few validated risk …
Peroxisome proliferator-activated receptor-α regulates fatty acid utilization in primary human skeletal muscle cells
In humans, skeletal muscle is a major site of peroxisome proliferator–activated receptor-α (PPAR-α)
expression, but its function in this tissue is unclear. We investigated the role of …
expression, but its function in this tissue is unclear. We investigated the role of …
Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system
…, TK Tippin, JG Wilson, DA Winegar… - Molecular …, 2002 - academic.oup.com
The nuclear oxysterol receptors liver X receptor-α [LXRα (NR1H3)] and LXRβ (NR1H2)
coordinately regulate genes involved in cholesterol homeostasis. Although both LXR subtypes …
coordinately regulate genes involved in cholesterol homeostasis. Although both LXR subtypes …
Identification of a subtype selective human PPARα agonist through parallel-array synthesis
…, LW Stuart, KP Hurley, MC Lewis, DA Winegar… - Bioorganic & medicinal …, 2001 - Elsevier
Using solid-phase, parallel-array synthesis, a series of urea-substituted thioisobutyric acids
was synthesized and assayed for activity on the human PPAR subtypes. GW7647 (3) was …
was synthesized and assayed for activity on the human PPAR subtypes. GW7647 (3) was …
Venous thromboembolism after bariatric surgery performed by Bariatric Surgery Center of Excellence Participants: analysis of the Bariatric Outcomes Longitudinal …
DA Winegar, B Sherif, V Pate, EJ DeMaria - Surgery for Obesity and …, 2011 - Elsevier
… DA Winegar and B. Sherif are full-time employees of Surgical Review Corporation EJ DeMaria
is an educational or research grant recipient from Covidien/US Surgical and Stryker and …
is an educational or research grant recipient from Covidien/US Surgical and Stryker and …