Our understanding of the role of T cells in human disease is undergoing revision as a result
of the discovery of T‐helper 17 (Th17) cells, a unique CD4 + T‐cell subset characterized by …

Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of
rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, …

… Fox DA Biological therapies: a novel approach to the treatment of autoimmune disease. Am
J Med 9932-88, 1995 115. Weinblatt ME, Maddison PJ, Bulpitt KJ, Hazleman BL, Urowitz MB…

The early events leading to the development of rheumatoid arthritis (RA) remain unclear,
but formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …

Twenty-eight patients with refractory rheumatoid arthritis completed a randomized 24-week
double-blind crossover trial comparing oral methotrexate (2.5 to 5 mg every 12 hours for …

Introduction Rheumatoid arthritis (RA) is a complex and clinically heterogeneous autoimmune
disease. Currently, the relationship between pathogenic molecular drivers of disease in …

Calcium overload is suggested to play a fundamental role in the process of rod apoptosis in
chemical-induced and inherited retinal degenerations. However, this hypothesis has not …

Severe systemic lupus erythematosus affecting the kidney or central nervous system may
lead to organ failure or death despite treatment with high doses of corticosteroids. To evaluate …

Rheumatoid arthritis (RA) is an inflammatory arthritis that affects nearly 1% of the world’s
adults. RA is characterized by symmetric polyarticular inflammation of the synovium, typically of …

Rheumatoid arthritis (RA) is characterized by synovial joint inflammation and by development
of pathogenic humoral and cellular autoimmunity to citrullinated proteins. Neutrophil …