Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

…, GA Wells, HE Wichmann, PS Wild, C Willenborg… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

…, J Peden, J Erdmann, P Diemert, C Willenborg… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Large-scale association analysis identifies new risk loci for coronary artery disease

…, P Deloukas, S Kanoni, C Willenborg… - Nature …, 2013 - nature.com
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

…, B Kühnel, A Rendon, A Teumer, C Willenborg… - Nature …, 2009 - nature.com
The number and volume of cells in the blood affect a wide range of disorders including cancer
and cardiovascular, metabolic, infectious and immune conditions. We consider here the …

[HTML][HTML] The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study

…, SR Wang, Z Wang, SH Wild, C Willenborg… - PLoS …, 2015 - journals.plos.org
Genome-wide association studies (GWAS) have identified more than 100 genetic variants
contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHR …

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants

…, H Holm, M Fischer, T Kessler, C Willenborg… - Stroke, 2014 - Am Heart Assoc
Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …

The impact of low-frequency and rare variants on lipid levels

…, T Esko, JS Ried, CP Nelson, C Willenborg… - Nature …, 2015 - nature.com
Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes
Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, …

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

…, S Eck, Z Aherrahrou, J Nahrstaedt, C Willenborg… - Nature, 2013 - nature.com
Myocardial infarction, a leading cause of death in the Western world 1 , usually occurs when
the fibrous cap overlying an atherosclerotic plaque in a coronary artery ruptures. The …

[HTML][HTML] Genetically determined height and coronary artery disease

…, TL Assimes, S Kanoni, C Willenborg… - … England Journal of …, 2015 - Mass Medical Soc
Background The nature and underlying mechanisms of an inverse association between
adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a …

Systematic evaluation of pleiotropy identifies 6 further loci associated with coronary artery disease

…, J Kruppa, A Mahajan, RA Scott, C Willenborg… - Journal of the American …, 2017 - jacc.org
Background : Genome-wide association studies have so far identified 56 loci associated with
risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also …