User profiles for Christian Lood
Christian LoodAssociate Professor Medicine, University of Washington Verified email at uw.edu Cited by 5731 |
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
C Lood, LP Blanco, MM Purmalek… - Nature medicine, 2016 - nature.com
Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19
Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by
respiratory failure. Although it has been suggested that elevated levels of blood neutrophils …
respiratory failure. Although it has been suggested that elevated levels of blood neutrophils …
Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease
…, M Martin, B Gullstrand, H Tydén, C Lood… - The Journal of …, 2012 - journals.aai.org
Ongoing inflammation including activation of the complement system is a hallmark of
systemic lupus erythematosus (SLE). Antimicrobial neutrophil extracellular traps (NETs) are …
systemic lupus erythematosus (SLE). Antimicrobial neutrophil extracellular traps (NETs) are …
Neutrophil extracellular traps as a potential source of autoantigen in cocaine-associated autoimmunity
C Lood, GC Hughes - Rheumatology, 2017 - academic.oup.com
Objective. Exposure to illicit cocaine and its frequent adulterant, levamisole, is associated
with ANCAs targeting neutrophil elastase (NE), neutropenia and vasculitic/thrombotic skin …
with ANCAs targeting neutrophil elastase (NE), neutropenia and vasculitic/thrombotic skin …
TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA
Neutrophils play a crucial role in host defense. However, neutrophil activation is also linked
to autoimmune diseases such as systemic lupus erythematosus (SLE), where nucleic acid–…
to autoimmune diseases such as systemic lupus erythematosus (SLE), where nucleic acid–…
Circulating microRNA expression profiles associated with systemic lupus erythematosus
…, AJ Schetter, CT Nielsen, C Lood… - Arthritis & …, 2013 - Wiley Online Library
Objective To evaluate the specificity of expression patterns of cell‐free circulating microRNAs
(miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was purified from …
(miRNAs) in systemic lupus erythematosus (SLE). Methods Total RNA was purified from …
Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated …
C Lood, S Amisten, B Gullstrand… - Blood, The Journal …, 2010 - ashpublications.org
Patients with systemic lupus erythematosus (SLE) have a markedly increased risk to develop
cardiovascular disease, and traditional cardiovascular risk factors fail to account for this …
cardiovascular disease, and traditional cardiovascular risk factors fail to account for this …
[HTML][HTML] Cell-free DNA as a biomarker in autoimmune rheumatic diseases
Endogenous DNA is primarily found intracellularly in nuclei and mitochondria. However,
extracellular, cell-free (cf) DNA, has been observed in several pathological conditions, including …
extracellular, cell-free (cf) DNA, has been observed in several pathological conditions, including …
C1q inhibits immune complex–induced interferon‐α production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus …
C Lood, B Gullstrand, L Truedsson… - … : Official Journal of …, 2009 - Wiley Online Library
Objective C1q deficiency is the strongest risk factor known for the development of systemic
lupus erythematosus (SLE), since almost all humans with a genetic deficiency of C1q develop …
lupus erythematosus (SLE), since almost all humans with a genetic deficiency of C1q develop …
[HTML][HTML] Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia
Background Neutrophils release neutrophil extracellular traps (NETs) in response to
invading pathogens. Although NETs play an important role in host defense against microbial …
invading pathogens. Although NETs play an important role in host defense against microbial …