Background Users of typical antipsychotic drugs have an increased risk of serious ventricular
arrhythmias and sudden cardiac death. However, less is known regarding the cardiac …

Objective To compare the prevalence and severity of coronary‐artery atherosclerosis in
patients with early and established rheumatoid arthritis (RA) and controls. Methods Electron‐…

Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis. The metabolic
syndrome, a cluster of cardiovascular risk factors, identifies cardiovascular risk. We tested the …

Importance Long-acting opioids increase the risk of unintentional overdose deaths but also
may increase mortality from cardiorespiratory and other causes. Objective To compare all-…

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood
pressure to identify genes, tissues, phenomes and medication contexts of blood pressure …

Purpose Bleeding complications are a serious adverse effect of medications that prevent
abnormal blood clotting. To facilitate epidemiologic investigations of bleeding complications, …

Background: Proton-pump inhibitors (PPIs) and clopidogrel are frequently coprescribed,
although the benefits and harms of their concurrent use are unclear. Objective: To examine the …

Background: The metabolic syndrome is an independent risk factor for ischaemic heart
disease. Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis; …

Objective Rheumatoid arthritis (RA) is an inflammatory disease associated with premature
atherosclerosis. We hypothesized that mediators of inflammation associated with …

Objective Insulin resistance is increased by inflammation, but the mechanisms are unclear.
The present study was undertaken to test the hypothesis that decreased insulin sensitivity is …