Objective To investigate whether periosteal cells from adult humans have features of multipotent
mesenchymal stem cells (MSCs) at the single‐cell level. Methods Cell populations were …

Lactate has long been considered a “waste” by-product of cell metabolism, and it accumulates
at sites of inflammation. Recent findings have identified lactate as an active metabolite in …

Background Follicular structures resembling germinal centres (GCs) that are characterized
by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

Ectopic lymphoid-like structures often develop at sites of inflammation where they influence
the course of infection, autoimmune disease, cancer and transplant rejection. These …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in remission, …

Patients with rheumatoid arthritis (RA) receive highly targeted biologic therapies without
previous knowledge of target expression levels in the diseased tissue. Approximately 40% of …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context of …

Background Although targeted biological treatments have transformed the outlook for
patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is …

CXCL13 and CCL21 have been functionally implicated in lymphoid tissue organization both
in the upstream phases of lymphoid tissue embryogenesis and in ectopic lymphoid …