Tocilizumab inhibits structural joint damage and improves physical function in patients with rheumatoid arthritis and inadequate responses to methotrexate: LITHE …

…, M Brzosko, R Burgos-Vargas, C Mela… - The Journal of …, 2013 - jrheum.org
Objective. To assess radiographic progression, physical function, clinical disease activity,
and safety in patients with rheumatoid arthritis (RA) who had inadequate response to …

[HTML][HTML] Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

J Xu, H Ma, H Ma, W Jiang, CA Mela, M Duan… - Nature …, 2020 - nature.com
Genomic DNA is folded into a higher-order structure that regulates transcription and maintains
genomic stability. Although progress has been made on understanding biochemical …

Switch from inhibitory to activating NKG2 receptor expression in HIV-1 infection: lack of reversion with highly active antiretroviral therapy

CM Mela, CT Burton, N Imami, M Nelson, A Steel… - Aids, 2005 - journals.lww.com
Background: HIV-1 infection is characterized by increase in inhibitory receptors and loss of
activating receptors on natural killer (NK) cells, resulting in loss of cell activity. Exceptionally, …

The RA-MAP Consortium: a working model for academia–industry collaboration

…, MF McDermott, IB McInnes, CM Mela… - Nature Reviews …, 2018 - nature.com
Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner,
multi-national cooperatives and research networks in the biomedical sector have …

Real-time dual-modal vein imaging system

CA Mela, DP Lemmer, FS Bao, F Papay… - International journal of …, 2019 - Springer
Purpose In this paper, we present a vein imaging system to combine reflectance mode visible
spectrum images (VIS) with transmission mode near-infrared (NIR) images in real time. …

Effect of rituximab on physical function and quality of life in patients with rheumatoid arthritis previously untreated with methotrexate

…, G Armstrong, A Jahreis, L Burke, C Mela… - Arthritis care & …, 2011 - Wiley Online Library
Objective To assess the effect of rituximab plus methotrexate (MTX) compared with MTX
alone on patient‐reported outcomes (PROs) and health‐related quality of life (HRQOL) in …

[PDF][PDF] Clinical efficacy and safety maintained up to 5 years in patients with rheumatoid arthritis treated with tocilizumab in a randomised trial

…, M Brzosko, R Burgos-Vargas, CM Mela… - Clin Exp …, 2016 - clinexprheumatol.org
… Kremer, MD Ricardo Blanco, MD, PhD Anne-Marie Halland, MBChB, FCP, MMED Marek
Brzosko, MD, PhD Ruben Burgos-Vargas, MD Christopher M. Mela, PhD Lucy Rowell, MSc …

The contribution of cytomegalovirus to changes in nk cell receptor expression in HIV-1–infected individuals

CM Mela, MR Goodier - The Journal of infectious diseases, 2007 - academic.oup.com
To the Editor—Gumá et al.[1] reported interesting findings regarding the influence of human
cytomegalovirus (HCMV) infection on the distribution of NK cell subsets bearing inhibitory …

NKG2C+ NK Cells Contribute to Increases in CD16+CD56 Cells in HIV Type 1+ Individuals with High Plasma Viral Load

JNS Gregson, L Kuri-Cervantes, CM Mela… - AIDS research and …, 2013 - liebertpub.com
Chronic HIV-1 infection results in the expansion of both NKG2C + and CD16 + CD56 −
human natural killer cells. NKG2C + cells proliferate in response to human cytomegalovirus (…

Evidence of bioequivalence and positive patient user handling of a tocilizumab autoinjector

S Fettner, C Mela, F Wildenhahn… - Expert Opinion on …, 2019 - Taylor & Francis
Background: The anti–interleukin-6 receptor antibody tocilizumab is approved for subcutaneous
injection using a prefilled syringe (PFS). We report results from a bioequivalence study …