Digital clubbing, recognized by Hippocrates in the fifth century BC, is the outward hallmark
of pulmonary hypertrophic osteoarthropathy, a clinical constellation that develops secondary …

Fructose intake from added sugars has been implicated as a cause of nonalcoholic fatty
liver disease. Here we tested the hypothesis that fructose may interact with a high‐fat diet to …

Fructose intake from added sugars correlates with the epidemic rise in obesity, metabolic
syndrome, and nonalcoholic fatty liver disease. Fructose intake also causes features of …

Carbohydrates with high glycaemic index are proposed to promote the development of
obesity, insulin resistance and fatty liver, but the mechanism by which this occurs remains …

Ketohexokinase (KHK, also known as fructokinase) initiates the pathway through which
most dietary fructose is metabolized. Very little is known about the cellular localization of this …

Diabetes is associated with activation of the polyol pathway, in which glucose is converted
to sorbitol by aldose reductase. Previous studies focused on the role of sorbitol in mediating …

A diverse family of cytoskeletal dynein motors powers various cellular transport systems,
including axonemal dyneins generating the force for ciliary and flagellar beating essential to …

Cilia are highly conserved microtubule-based structures that perform a variety of sensory
and motility functions during development and adult homeostasis. In humans, defects …

In human cells DNA double strand breaks (DSBs) can be repaired by the non-homologous
end-joining (NHEJ) pathway. In a background of NHEJ deficiency, DSBs with mismatched …

Infantile myopathies with diaphragmatic paralysis are genetically heterogeneous, and
clinical symptoms do not assist in differentiating between them. We used phased haplotype …