Churg-Strauss syndrome (CSS) is a disorder characterized by hypereosinophilia and systemic
vasculitis occurring in individuals with asthma and allergic rhinitis. The prevailing view of …

Systemic vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens (ANCA)
is the most frequent cause of rapidly progressive glomerulonephritis. Renal failure at …

Background Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …

Background: Current therapies for antineutrophil cytoplasmic antibody (ANCA)–associated
vasculitis are limited by toxicity. Objective: To compare pulse cyclophosphamide with daily …

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is the most common
cause of rapidly progressive glomerulonephritis worldwide, and the renal biopsy is the gold …

Identification of the genes underlying complex phenotypes and the definition of the
evolutionary forces that have shaped eukaryotic genomes are among the current challenges in …

Background: Anti–glomerular basement membrane (GBM) antibody disease is an
autoantibody-mediated disorder that usually presents as rapidly progressive glomerulonephritis, …

[Formula: see text] Renal involvement is frequently present in antineutrophil cytoplasmic
autoantibody (ANCA)-associated systemic vasculitis and is an important cause of end-stage …

Background More effective and safer treatments are needed for antineutrophil cytoplasmic
antibody (ANCA)–associated vasculitis. Methods We conducted a randomized trial with a 2-by…

Naturally occurring variation in gene copy number is increasingly recognized as a heritable
source of susceptibility to genetically complex diseases. Here we report strong association …