Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is
ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed …

The molecular and cellular processes that lead to renal damage and to the heterogeneity of
lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (…

Objective. —To determine whether the severity of septic encephalopathy is correlated with
gram-negative bacteremia and mortality and whether there exists a single or combination of …

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a
broad spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70% …

Systemic Lupus Erythematosus (SLE) typically affects females at far greater rates than males;
however male SLE patients often have more severe disease than females. The gender …

Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

Nephrophilic autoantibodies dominate the seroprofile in lupus, but their fine specificities
remain ill defined. We constructed a multiplexed proteome microarray bearing about 30 …

The metabolic disturbances that underlie systemic lupus erythematosus are currently unknown.
A metabolomic study was executed, comparing the sera of 20 SLE patients against that …

Anti-DNA Abs commonly found in patients with systemic lupus erythematosus are thought to
play an important pathogenic role in lupus nephritis. Anti-DNA Abs may contribute to renal …

Introduction TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator
of chronic inflammatory processes via prolonged activation of the NF-κB pathway in several …