Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with
complex etiology but strong clustering in families (λ S = ∼30). We performed a genome-wide …

Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These
cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-…

We report on the production of tumor necrosis factor (TNF)-alpha and TNF-beta by mitogen-activated
peripheral blood lymphocytes or enriched monocyte subpopulations from human …

The (NZB×NZW)F 1 hybrid mouse develops a severe autoimmune disease similar to systemic
lupus erythematosus in humans. Both the human and murine form of the disease show …

Previous studies have suggested more than 20 genetic intervals that are associated with
susceptibility to type 1 diabetes (T1D) 1 , 2 , but identification of specific genes has been …

The (NZB X NZW)F1 mouse is recognized as an important animal model of the human disease
systemic lupus erythematosus (SLE). Groups of NZB/W F1 mice were treated either with …

Linkage disequilibrium (association) analysis was used to evaluate a candidate region near
the CTLA4/CD28 genes using a multi-ethnic collection of families with one or more children …

The role of tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of autoimmune
diabetes mellitus was tested in the nonobese mouse (NOD) model system. The effects of TNF-…

Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using Immunochip …

A combined forward and reverse genetic approach was undertaken to test the candidacy of
IRAK1 (interleukin-1 receptor associated kinase-1) as an X chromosome-encoded risk factor …