The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …

Twin studies have provided the basis for genetic and epidemiological studies in human
complex traits 1 , 2 . As epigenetic factors can contribute to phenotypic outcomes, we conducted …

Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently
found in human glioblastomas 1 and cytogenetically normal acute myeloid leukaemias (AML) …

Large-scale genomic studies have identified multiple somatic aberrations in breast cancer,
including copy number alterations and point mutations. Still, identifying causal variants and …

This work is dedicated to the development of a technology for unbiased, high-throughput
DNA methylation profiling of large genomic regions. In this method, unmethylated and …

Epigenetics represents a secondary inheritance system that has been poorly investigated in
human biology. The objective of this study was to perform a comprehensive analysis of DNA …

Background Classification of high-grade neuroendocrine tumours (HGNT) of the lung currently
recognises large-cell neuroendocrine carcinoma (LCNEC) and small-cell lung carcinoma …

Background The clinical utility of molecular profiling of tumor tissue to guide treatment of
patients with advanced solid tumors is unknown. Our objectives were to evaluate the frequency …

Human pluripotent stem cells (hPSCs) represent a novel source of hepatocytes for drug
metabolism studies and cell-based therapy for the treatment of liver diseases. These …

Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in
cellular signaling. All Class I PTPs contain an essential active site cysteinyl residue, which …