We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Given the anthropometric differences between men and women and previous evidence of
sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic …

Malaria causes approximately one million fatalities per year, mostly among African children
1 . Although highlighted by the strong protective effect of the sickle-cell trait 2 , 3 , the full …

… Klopp, Christina Loley, Klaus Stark, … C, MAF 0.44 in HapMap CEU) leads to a missense
variant (p.Ser1002Thr) which is located in exon 3 of the KIAA1462 gene. The minor allele C …

Background— Recent genome-wide association studies (GWAS) have identified several
novel loci that reproducibly associate with coronary artery disease (CAD) and/or myocardial …

BACKGROUND. Understanding the genetic architecture of cardiac structure and function
may help to prevent and treat heart disease. This investigation sought to identify common …

In current genome‐wide association studies (GWAS), the analysis is usually focused on
autosomal variants only, and the sex chromosomes are often neglected. Recently, a number of …

Hypertension is a risk factor for coronary artery disease. Recent genome-wide association
studies have identified 30 genetic variants associated with higher blood pressure at genome-…

… The AGXT2 variant rs37369 in exon 4 is characterized by a C>T exchange, resulting in
an amino acid exchange from valine to isoleucine at position 140 (Val140Ile). These …

… Three independent samples (OHGS-A, OHGS-B and OHGS-C) were ascertained
consecutively for this study. OHGS cases: Individuals with documented CAD (stenosis in a major …