… (C-mock), a C-terminal HA-tagged pUNO-TLR3 WT vector (C-… C-TLR3 P554S) upon
stimulation with various doses of poly(I:… controls (C), P1, and P2, upon stimulation with poly(I:C) or …

NKp46 + CD3 − natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver
and uterus can produce granule-dependent cytotoxicity and interferon-γ. Here we identify in …

… HLA-C alleles characterized by Lys at position 80 (HLA-C Lys80 , also named C2 group),
KIR2DL2/3 recognizes HLA-C alleles characterized by Asn at position 80 (HLA-C Asn80 , C1 …

… Targeted exome sequencing in 8 patients identified a variant (c.71-1insG) in minichromosome
maintenance–deficient 4 (MCM4) that was predicted to result in a severely truncated …

… Genista phenotype; C. Bernat identified the NK cell functional defect present in Genista;
BN Jaeger performed and analyzed the experiments on mice; C. Cognet performed and …

… Cells were then incubated at 37C with 5% CO 2 in the presence or absence of the following
stimuli: 300 ng/mL synthetic bacterial lipoprotein (Pam3CSK4), 10 µg/mL zymosan, 10 8 cells…

… (c) Tumour take was assessed on the basis of palpability; the results are expressed as the
percentage of tumour-free mice at the indicated time points after cell injection. P values were …

Rationale Natural killer cells, as a major source of interferon-γ, contribute to the amplification
of the inflammatory response as well as to mortality during severe sepsis in animal models. …

… In these assays, PBMCs were incubated for 4 hours at 37C … 1 mM EDTA and stained for 30
minutes at 4C with PerCP-Cy5.5–… –IFN-γ for 30 minutes at 4C. As a negative control, species- …

Objective: The mechanisms involved in cytomegalovirus reactivation in critically ill patients
who were previously immunocompetent are still unknown. The current study was designed to …