Objective To describe the clinical and laboratory features of macrophage activation syndrome
as a complication of juvenile systemic lupus erythematosus (SLE). Methods Cases of …

… This leads to recruitment of signal transducer and activator of transcription 1 (STAT1),
which binds to IFNGR1 and is phosphorylated in the C terminus by JAK1 and JAK2. …

… In these mice, administration of Toll-like receptor (TLR) ligands, including lipopolysaccharides
(LPS) and poly(I:C), induces the development of MAS by mimicking an acute infection on …

… HSP, 150 c-PAN, 60 c-WG, 87 c-TA and 59 c-other. Prevalence, signs/symptoms,
laboratory, biopsy and imaging reports were consistent with the clinical picture of the four c-vasculitides…

Objectives Interferon-γ (IFNγ) is the pivotal mediator in murine models of primary haemophagocytic
lymphohistiocytosis (pHLH). Given the similarities between primary and secondary …

… B and C, Expression of perforin and granzyme B (B) and production of IFNg (C),
determined as the MFI and percentage of IFNg1DX51CD3 2 NK cells. In A (right), B, and …

Background Most data for treatment of dermatomyositis and juvenile dermatomyositis are
from anecdotal, non-randomised case series. We aimed to compare, in a randomised trial, the …

… Laboratory monitoring included white blood cell (WBC) count, hemoglobin, platelet count,
erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), alanine transaminase (ALT), …

… R186C amino acid substitution occurs in a unique region at the C-terminus, within the …
impact of amino acid substitutions in regions far from the C-terminal tail on RhoGDI binding, which …

… was subjected to an initial denaturation of 8 min at 95C followed by 40 amplification cycles
of denaturation for 30s at 95C, annealing for 40s at 55C, and extension for 1 min at 72C. …