Clinical trials in head injury

…, MR Bullock, SC Choi, GL Clifton, CF Contant… - Journal of …, 2002 - liebertpub.com
Traumatic brain injury (TBI) remains a major public health problem globally. In the United
States the incidence of closed head injuries admitted to hospitals is conservatively estimated to …

[HTML][HTML] Clopidogrel with or without omeprazole in coronary artery disease

DL Bhatt, BL Cryer, CF Contant, M Cohen… - … England Journal of …, 2010 - Mass Medical Soc
Background Gastrointestinal complications are an important problem of antithrombotic
therapy. Proton-pump inhibitors (PPIs) are believed to decrease the risk of such complications, …

Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis

…, JL Mas, J Röther, SC Smith, G Salette, CF Contant… - Jama, 2010 - jamanetwork.com
Context Clinicians and trialists have difficulty with identifying which patients are highest risk
for cardiovascular events. Prior ischemic events, polyvascular disease, and diabetes mellitus …

Prevention of secondary ischemic insults after severe head injury

…, AB Valadka, HJ Hannay, CF Contant… - Critical care …, 1999 - journals.lww.com
Objective: The purpose of this study was to compare the effects of two acute-care management
strategies on the frequency of jugular venous desaturation and refractory intracranial …

High-dose barbiturate control of elevated intracranial pressure in patients with severe head injury

HM Eisenberg, RF Frankowski, CF Contant… - Journal of …, 1988 - thejns.org
✓ In a five-center study, 73 patients with severe head injury and elevated intracranial
pressure (ICP) were randomly assigned to receive either a regimen that included high-dose …

Jugular venous desaturation and outcome after head injury.

SP Gopinath, CS Robertson, CF Contant… - Journal of Neurology …, 1994 - jnnp.bmj.com
Early experience with continuous monitoring of jugular venous oxygen saturation (SjvO2)
suggested that this technology might allow early identification of global cerebral ischaemia in …

Relationship of brain tissue PO2 to outcome after severe head injury

AB Valadka, SP Gopinath, CF Contant… - Critical care …, 1998 - journals.lww.com
… MD; Contant, Charles F. PhD; Uzura, Masahiko MD; Robertson, Claudia S. MD …
Gopinath SP, Robertson CS, Contant CF, et al: Jugular venous desaturation and outcome …

Continuous monitoring of jugular venous oxygen saturation in head-injured patients

…, MJ Kanter, CS Robertson, CF Contant… - Journal of …, 1992 - thejns.org
✓ The continuous measurement of jugular venous oxygen saturation (SjvO 2 ) with a fiberoptic
catheter is evaluated as a method of detecting cerebral ischemia after head injury. Forty-…

Effect of head elevation on intracranial pressure, cerebral perfusion pressure, and cerebral blood flow in head-injured patients

Z Feldman, MJ Kanter, CS Robertson, CF Contant… - Journal of …, 1992 - thejns.org
… Kety SS, Schmidt CF: The determination of cerebral blood flow in man by the use of nitrous
oxide in low concentrations. Am J Physiol 143:53-66, 1945 7. Kety SS, Schmidt CF: The …

Adult respiratory distress syndrome: a complication of induced hypertension after severe head injury

CF Contant, AB Valadka, SP Gopinath… - Journal of …, 2001 - thejns.org
Object. The factors involved in the development of adult respiratory distress syndrome (ARDS)
after severe head injury were studied. The presence of ARDS complicates the treatment …