Genome-wide association studies and fine mapping of candidate regions have rapidly
advanced our understanding of the genetic basis of systemic lupus erythematosus (SLE). More …

Mapping by admixture linkage disequilibrium (LD) detected strong association between
nonmuscle myosin heavy chain 9 gene (MYH9) variants on chromosome 22 and nondiabetic …

Human genetic diversity is the result of population genetic forces. This genetic variation
influences disease risk and contributes to health disparities. Autoimmune diseases (ADs) are a …

Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

African Americans have higher rates of kidney disease than European Americans. Here, we
show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with
complex etiology but strong clustering in families (λ S = ∼30). We performed a genome-wide …

We genotyped 525 independent North American white individuals with systemic lupus
erythematosus (SLE) for the PTPN22 R620W polymorphism and compared the results with data …

Objective: To evaluate the effect of a patient, healthcare provider, and systems intervention
on the prevalence of risk factors for lower extremity amputation in patients with non–insulin-…

We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …