Recently published articles have described criteria to assess qualitative research in the
health field in general, but very few articles have delineated qualitative methods to be used in …

Background: Disease-modifying antirheumatic drugs may confer greater benefits when
combined with the antimetabolite methotrexate. Objective: To evaluate the efficacy and safety of …

Recently, mixed treatment comparisons (MTC) have been presented as an extension of
traditional meta-analysis by including multiple different pairwise comparisons across a range of …

Economic evaluation conducted in terms of cost per quality-adjusted life-year (QALY) provides
information that decision makers find useful in many parts of the world. Ideally, clinical …

Objective To examine correlations between clinical improvement as defined by the
American College of Rheumatology (ACR) responder analysis and clinical improvement as …

Objective To assess the efficacy of leflunomide or methotrexate compared with placebo in
improving function and health‐related quality of life in patients with active rheumatoid arthritis (…

Cost-effectiveness models that present results in terms of cost per quality-adjusted life-year
for health technologies are used to inform policy decisions in many parts of the world. Health …

The validity of estimates of resource utilisation based on patient recall has not been firmly
established. A comprehensive literature search was conducted to identify studies that used …

Objective: Poor medication adherence is widespread among patients with chronic conditions
requiring long-term drug therapy. Medication adherence is determined by multiple patient-, …

Although cough and sputum production may impact patients' well being and functioning in
COPD and chronic bronchitis, there is no validated instrument for cough and sputum …