[HTML][HTML] Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia
…, AJ Johnson, J Sukbuntherng, BY Chang… - … England Journal of …, 2013 - Mass Medical Soc
Background The treatment of relapsed chronic lymphocytic leukemia (CLL) has resulted in
few durable remissions. Bruton's tyrosine kinase (BTK), an essential component of B-cell–…
few durable remissions. Bruton's tyrosine kinase (BTK), an essential component of B-cell–…
[HTML][HTML] Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma
…, J McGreivy, F Clow, JJ Buggy, BY Chang… - … England Journal of …, 2013 - Mass Medical Soc
Background Bruton's tyrosine kinase (BTK) is a mediator of the B-cell–receptor signaling
pathway implicated in the pathogenesis of B-cell cancers. In a phase 1 study, ibrutinib, a BTK …
pathway implicated in the pathogenesis of B-cell cancers. In a phase 1 study, ibrutinib, a BTK …
[HTML][HTML] A mitochondrial protein compendium elucidates complex I disease biology
Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of human
diseases. Identifying all of the proteins resident in this organelle and understanding how …
diseases. Identifying all of the proteins resident in this organelle and understanding how …
The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
…, E Verner, D Loury, B Chang… - Proceedings of the …, 2010 - National Acad Sciences
Activation of the B-cell antigen receptor (BCR) signaling pathway contributes to the initiation
and maintenance of B-cell malignancies and autoimmune diseases. The Bruton tyrosine …
and maintenance of B-cell malignancies and autoimmune diseases. The Bruton tyrosine …
[HTML][HTML] Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib
…, S Stilgenbauer, JJ Buggy, BY Chang… - … England Journal of …, 2014 - Mass Medical Soc
Background Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and is
effective in chronic lymphocytic leukemia (CLL). Resistance to irreversible kinase inhibitors and …
effective in chronic lymphocytic leukemia (CLL). Resistance to irreversible kinase inhibitors and …
[HTML][HTML] Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies
…, RR Furman, S Rodriguez, BY Chang… - Journal of Clinical …, 2013 - ncbi.nlm.nih.gov
Purpose Survival and progression of mature B-cell malignancies depend on signals from
the B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in …
the B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in …
Targeting B cell receptor signaling with ibrutinib in diffuse large B cell lymphoma
…, JC Barrientos, J McGreivy, M Fardis, BY Chang… - Nature medicine, 2015 - nature.com
The two major subtypes of diffuse large B cell lymphoma (DLBCL)—activated B cell–like (ABC)
and germinal center B cell–like (GCB)—arise by distinct mechanisms, with ABC …
and germinal center B cell–like (GCB)—arise by distinct mechanisms, with ABC …
Fuzzy DEMATEL method for developing supplier selection criteria
B Chang, CW Chang, CH Wu - Expert systems with Applications, 2011 - Elsevier
Supply chain management (SCM) practices have flourished since the 1990s. Enterprises
realize that a large amount of direct and indirect profits can be obtained from effective and …
realize that a large amount of direct and indirect profits can be obtained from effective and …
Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes
…, JD Hessler, TM Liu, BY Chang… - Blood, The Journal …, 2013 - ashpublications.org
Given its critical role in T-cell signaling, interleukin-2–inducible kinase (ITK) is an appealing
therapeutic target that can contribute to the pathogenesis of certain infectious, autoimmune, …
therapeutic target that can contribute to the pathogenesis of certain infectious, autoimmune, …
[HTML][HTML] Changes in food consumption during the COVID-19 pandemic: analysis of consumer survey data from the first lockdown period in Denmark, Germany, and …
This paper focuses on changes in food consumption that occurred during the COVID-19
pandemic. Its objective is to map changes at individual consumer level and identify the influence …
pandemic. Its objective is to map changes at individual consumer level and identify the influence …