Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and
ethnic disparities. We report a large transancestral association study of SLE using Immunochip …

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis.
The study of synovial tissue has advanced considerably throughout the past few decades …

NK cell populations were derived from murine splenocytes stimulated by IL-2, IL-15, or the
combination of IL-12 and IL-18. Whereas NK cells derived with the latter cytokines consisted …

Objective We developed interferon‐α–kinoid (IFN‐K), a drug composed of inactivated IFNα
coupled to a carrier protein, keyhole limpet hemocyanin. In human IFNα–transgenic mice, IFN…

Background Although an early decrease in proteinuria has been correlated with good long-term
renal outcome in lupus nephritis (LN), studies aimed at defining a cut-off proteinuria …

A recent genome-wide association study revealed a variant (rs2431697) in an intergenic
region, between the pituitary tumor-transforming 1 (PTTG1) and microRNA (miR-146a) genes, …

We investigated the effects of IL-12 and IL-18 on unstimulated murine splenocytes and
observed that the two cytokines strongly synergized for their proliferation, whereas IL-12 and IL-…

SLE is an autoimmune condition characterized by loss of tolerance to chromatin constituents
and the production of ANAs. The majority of SLE patients display spontaneous expression …

10.7554/eLife.12089.001 Targeted sequencing of sixteen SLE risk loci among 1349
Caucasian cases and controls produced a comprehensive dataset of the variations causing …

Objective To compare the effects of methotrexate (MTX), alone or in combination with
intravenous (IV) methylprednisolone (MP) or infliximab, on magnetic resonance imaging (MRI)–…