User profiles for BRUCE KIRKHAM

Bruce Kirkham

Professor of Translational Research, Kings College London
Verified email at gstt.nhs.uk
Cited by 17931

Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double-blind, placebo-controlled …

IB McInnes, PJ Mease, B Kirkham, A Kavanaugh… - The Lancet, 2015 - thelancet.com
Background Interleukin 17A is a proinflammatory cytokine that is implicated in the pathogenesis
of psoriatic arthritis. We assessed the efficacy and safety of subcutaneous secukinumab, …

Sustained benefits of infliximab therapy for dermatologic and articular manifestations of psoriatic arthritis: results from the infliximab multinational psoriatic arthritis …

CE Antoni, A Kavanaugh, B Kirkham… - Arthritis & …, 2005 - Wiley Online Library
Objective To investigate the efficacy and tolerability of infliximab therapy for the articular and
dermatologic manifestations of active psoriatic arthritis (PsA). Methods One hundred four …

[HTML][HTML] Secukinumab inhibition of interleukin-17A in patients with psoriatic arthritis

PJ Mease, IB McInnes, B Kirkham… - … England Journal of …, 2015 - Mass Medical Soc
Background In a phase 2 study, the inhibition of the interleukin-17A receptor improved signs
and symptoms of psoriatic arthritis. We sought to evaluate the efficacy and safety of …

[HTML][HTML] Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium

…, A Manzo, S Kelly, MC Blades, B Kirkham… - PLoS …, 2009 - journals.plos.org
Background Follicular structures resembling germinal centres (GCs) that are characterized
by follicular dendritic cell (FDC) networks have long been recognized in chronically inflamed …

Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two‐year prospective study (the DAMAGE study cohort)

BW Kirkham, MN Lassere, JP Edmonds… - Arthritis & …, 2006 - Wiley Online Library
Objective The primary aim of this prospective 2‐year study was to explain the wide variability
in joint damage progression in patients with rheumatoid arthritis (RA) from measures of …

Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin‐17 receptor IgG1 Fc fusion protein

…, KM Farmer, JS Walker, BW Kirkham - Arthritis & …, 2002 - Wiley Online Library
Objective To investigate the role of interleukin‐17 (IL‐17) in inflammatory arthritis by
blockade with an IL‐17 receptor/human IgG1 Fc fusion protein (muIL‐17R:Fc) in adjuvant‐induced …

Ixekizumab for the treatment of patients with active psoriatic arthritis and an inadequate response to tumour necrosis factor inhibitors: results from the 24-week …

P Nash, B Kirkham, M Okada, P Rahman, B Combe… - The Lancet, 2017 - thelancet.com
Background Patients who have had inadequate response to tumour necrosis factor inhibitors
have fewer treatment options and are generally more treatment refractory to subsequent …

Enthesitis: from pathophysiology to treatment

…, MA D'Agostino, D Elewaut, B Kirkham… - Nature reviews …, 2017 - nature.com
Entheses are the insertion sites of tendons and ligaments to the bone surface and are
essential structures for locomotion. Inflammation of the entheses (enthesitis) is a key feature of …

Interleukin‐17A: a unique pathway in immune‐mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis

BW Kirkham, A Kavanaugh, K Reich - Immunology, 2014 - Wiley Online Library
Experimental evidence points to the importance of the cytokine interleukin‐17A ( IL ‐17A) in
the pathogenesis of several immunoinflammatory diseases including psoriasis, psoriatic …

Comparison of two etanercept regimens for treatment of psoriasis and psoriatic arthritis: PRESTA randomised double blind multicentre trial

W Sterry, JP Ortonne, B Kirkham, O Brocq, D Robertson… - Bmj, 2010 - bmj.com
Objectives To compare the efficacy over 12 weeks of two different etanercept regimens in
treating the skin manifestations of psoriasis in patients who also have psoriatic arthritis and to …