Treatment of rheumatoid arthritis with recombinant human interleukin‐1 receptor antagonist
B Bresnihan, JM Alvaro‐Gracia, M Cobby… - Arthritis & …, 1998 - Wiley Online Library
Objective To evaluate the efficacy and safety of interleukin‐1 receptor antagonist (IL‐1Ra)
in patients with rheumatoid arthritis (RA). Methods Patients with active and severe RA (…
in patients with rheumatoid arthritis (RA). Methods Patients with active and severe RA (…
Synovial tissue inflammation in early and late osteoarthritis
…, WB Van Den Berg, B Bresnihan - Annals of the …, 2005 - ard.bmj.com
Objective: To compare selected immunohistological features of inflammation in synovial
tissue from patients with early and late osteoarthritis (OA). Methods: Synovial tissue samples …
tissue from patients with early and late osteoarthritis (OA). Methods: Synovial tissue samples …
Synovial tissue macrophage populations and articular damage in rheumatoid arthritis
…, O Fitzgerald, B Bresnihan - Arthritis & Rheumatism …, 1996 - Wiley Online Library
Objective. To examine the relative contribution of individual synovial cell populations to
polyarticular destruction in rheumatoid arthritis (RA). Methods. Serial measurements of disease …
polyarticular destruction in rheumatoid arthritis (RA). Methods. Serial measurements of disease …
A multicenter, double‐blind, dose‐ranging, randomized, placebo‐controlled study of recombinant human interleukin‐1 receptor antagonist in patients with rheumatoid …
…, I Watt, M Cobby, B Bresnihan… - … : Official Journal of …, 2000 - Wiley Online Library
Objective To evaluate radiographic progression and the relationship of radiologic scores
obtained by the Genant and Larsen methods in a clinical trial of recombinant human interleukin…
obtained by the Genant and Larsen methods in a clinical trial of recombinant human interleukin…
[HTML][HTML] Women, men, and rheumatoid arthritis: analyses of disease activity, disease characteristics, and treatments in the QUEST-RA study
…, D Henrohn, B Bresnihan… - Arthritis research & …, 2009 - Springer
Introduction Gender as a predictor of outcomes of rheumatoid arthritis (RA) has evoked
considerable interest over the decades. Historically, there is no consensus whether RA is worse …
considerable interest over the decades. Historically, there is no consensus whether RA is worse …
Patient perspective: fatigue as a recommended patient centered outcome measure in rheumatoid arthritis.
…, P Minnock, A Adebajo, B Bresnihan… - The Journal of …, 2007 - jrheum.org
The Patient Perspective Workshop at OMERACT 8 considered evidence for the importance
of fatigue to patients with rheumatoid arthritis (RA) and whether measurement of fatigue …
of fatigue to patients with rheumatoid arthritis (RA) and whether measurement of fatigue …
Asymptomatic synovitis precedes clinically manifest arthritis
…, H Versendaal, M Jonker, B Bresnihan… - … : Official Journal of …, 1998 - Wiley Online Library
Objective It has been hypothesized that asymptomatic synovitis may precede clinical
manifestations of arthritis in the earliest phase of rheumatoid arthritis (RA). To obtain more insight …
manifestations of arthritis in the earliest phase of rheumatoid arthritis (RA). To obtain more insight …
A randomized controlled trial with an anti‐CCL2 (anti–monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis
…, F Van den Bosch, B Bresnihan… - … : Official Journal of …, 2006 - Wiley Online Library
Objective Chemokines such as CCL2/monocyte chemotactic protein 1 (MCP‐1) play a key
role in leukocyte migration and are potential targets in the treatment of chronic inflammatory …
role in leukocyte migration and are potential targets in the treatment of chronic inflammatory …
Systematic microanatomical analysis of CXCL13 and CCL21 in situ production and progressive lymphoid organization in rheumatoid synovitis
…, G Yanni, O FitzGerald, B Bresnihan… - European journal of …, 2005 - Wiley Online Library
CXCL13 and CCL21 have been functionally implicated in lymphoid tissue organization both
in the upstream phases of lymphoid tissue embryogenesis and in ectopic lymphoid …
in the upstream phases of lymphoid tissue embryogenesis and in ectopic lymphoid …
Analysis of the histologic variation of synovitis in rheumatoid arthritis
…, A Whelan, C Feighery, B Bresnihan - … : Official Journal of …, 1988 - Wiley Online Library
One hundred forty‐five synovial biopsy specimens were obtained from 30 procedures
performed on the knee joints of 29 patients with rheumatoid arthritis. All patients had clinically …
performed on the knee joints of 29 patients with rheumatoid arthritis. All patients had clinically …