Sex hormones seem to play an important role as modulators of the autoimmune disease
onset/perpetuation. Generally, steroid hormones are implicated in the immune response, with …

… IgG and IgM production by peripheral blood mononuclear cells (PBMCs) from SLE patients,
which leads to elevated levels of polyclonal IgG, including IgG anti-dsDNA by enhancing B …

… Since estrogen receptors are expressed on CD8+ T lymphocytes that display inhibitory
properties on antibody-producing B lymphocytes, the role of 17β-estradiol on B autoreactive cells …

… B, Suppressor activity, tested in a T cell proliferation assay, exerted by tumor-infiltrating
CD8+CD28− T cells from patients 3, 6, 7, 10–14, 16, 18–22, 25–32, 42 or CD8+CD28+ T cells …

The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy
is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with …

We examined the hypothesis that senescence represents a proximate mechanism by which
the kidney is damaged in type 2 diabetic nephropathy (DN). As a first step, we studied …

The circadian changes in the metabolism or nocturnal secretion of endogenous corticosteroids
(reduction) observed in rheumatoid arthritis (RA) patients are responsible, in part, for the …

The pineal hormone melatonin (MLT) exerts a variety of effects on the immune system. MLT
activates immune cells and enhances inflammatory cytokine and nitric oxide production. …

… (B) In UA treated cells the mitochondrial membrane potential is dissipated and the
Mitocapture dye is dispersed into the cell as green fluorescent monomers. (C) UA induces a …

Background: Altered functioning of the hypothalamic-pituitary-adrenal axis and altered melatonin
production might modulate the circadian symptoms in patients with rheumatoid arthritis. …