… recorded a B-cell signature that characterises patients with early-onset arthritis independently
from the number of joints affected. Their study accords with previous findings showing that …

… Despite the existence of several possible mechanisms for ensuring CENTRAL TOLERANCE
to self, self-HSP-specific T and B cells have been found in association with chronic …

Adipose tissue (AT) plays a pivotal role in whole-body lipid and glucose homeostasis. AT
exerts metabolic control through various immunological mechanisms that instigated a new …

Cytokines secreted by cells of the immune system can alter the behavior and properties of
immune or other cells. At a site of inflammation, sets of cytokines interact with immune cells, …

This study investigates the role of CD4+ CD25+ regulatory T cells during the clinical course
of juvenile idiopathic arthritis (JIA). Persistent oligoarticular JIA (pers-OA JIA) is a subtype of …

Background Growing knowledge about cellular interactions in the immune system, including
the central role of cytokine networks, has lead to new treatments using monoclonal …

Regulatory T cells (Tregs) are a specific subset of lymphocytes that are critical for the
maintenance of self-tolerance. Expression levels of the transcription factor Foxp3 have been …

Background: Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of disorders
with, for the most part, an unknown immunopathogenesis. Although onset and disease …

Stable Foxp3 expression is required for the development of functional regulatory T (Treg)
cells. Here, we demonstrate that the expression of the transcription factor Foxp3 can be …

Cytokines, chemokines and soluble adhesion molecules interact in a complex network within
the immune system. Fingerprinting of these proteins may allow the use of these proteins as …