Neutrophil extracellular traps that are not degraded in systemic lupus erythematosus activate complement exacerbating the disease

J Leffler, M Martin, B Gullstrand, H Tydén… - The Journal of …, 2012 - journals.aai.org
… Lower threshold for B cell activation has also been proposed as shown in one SLE mouse
… immune-modulatory effects, mainly focusing on induction of B cell anergy (12) (for a review, …

C1q inhibits immune complex–induced interferon‐α production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus …

C Lood, B Gullstrand, L Truedsson… - … : Official Journal of …, 2009 - Wiley Online Library
… Systemic lupus erythematosus (SLE) is a systemic autoimmune disease involving
several organ systems, and it is also characterized by the presence of B cell hyperreactivity, …

Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated …

C Lood, S Amisten, B Gullstrand… - Blood, The Journal …, 2010 - ashpublications.org
Patients with systemic lupus erythematosus (SLE) have a markedly increased risk to develop
cardiovascular disease, and traditional cardiovascular risk factors fail to account for this …

Increased IgG on cell‐derived plasma microparticles in systemic lupus erythematosus is associated with autoantibodies and complement activation

…, LV Iversen, L Truedsson, B Gullstrand… - Arthritis & …, 2012 - Wiley Online Library
… A and solvent B (95% [v/v] acetonitrile and 0.1% [v/v] formic acid). The gradient went from
0% to 35% solvent B in 60 minutes, followed by 10 minutes with 100% solvent B; then data …

[HTML][HTML] Degradation of neutrophil extracellular traps co-varies with disease activity in patients with systemic lupus erythematosus

J Leffler, B Gullstrand, A Jönsen, JÅ Nilsson… - Arthritis research & …, 2013 - Springer
… The ability of serum to degrade NETs compared to internal control of serum from 77 healthy
controls (A) and 69 patients with SLE followed during multiple time points (B). Dashed line …

A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus

LM Olsson, ÅC Johansson, B Gullstrand… - Annals of the …, 2017 - ard.bmj.com
Objectives Ncf1 polymorphisms leading to low production of reactive oxygen species (ROS)
are strongly associated with autoimmune diseases in animal models. The human NCF1 …

Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells

B Gullstrand, U Mårtensson, G Sturfelt… - Clinical & …, 2009 - academic.oup.com
Inherited deficiencies in components of the classical complement pathway are strong disease
susceptibility factors for the development of systemic lupus erythematosus (SLE) and there …

Increased serum levels of S100A8/A9 and S100A12 are associated with cardiovascular disease in patients with inactive systemic lupus erythematosus

H Tydén, C Lood, B Gullstrand, A Jönsen… - …, 2013 - academic.oup.com
… 2B) as compared with SLE patients with no CVD or venous thromboembolism (median
S100A8/A9 concentration 7528 ng/ml; median S100A12 concentration 177 ng/ml). Furthermore, …

Platelet‐derived S100A8/A9 and cardiovascular disease in systemic lupus erythematosus

C Lood, H Tydén, B Gullstrand, A Jönsen… - Arthritis & …, 2016 - Wiley Online Library
… and C, Photomicrographs showing platelet S100A8/A9 on the cell surface (B), in particular
upon cell–cell contact (C), and in granules (B and C). D and E, Photomicrographs showing …

Pro-inflammatory S100 proteins are associated with glomerulonephritis and anti-dsDNA antibodies in systemic lupus erythematosus

H Tydén, C Lood, B Gullstrand, A Jönsen, F Ivars… - Lupus, 2017 - journals.sagepub.com
Objectives Systemic lupus erythematosus (SLE) is associated with elevated levels of S100A8/A9,
pro-inflammatory proteins mainly secreted by activated polymorphonuclear neutrophils …