User profiles for B. W. Kirkham

Bruce Kirkham

Professor of Translational Research, Kings College London
Verified email at gstt.nhs.uk
Cited by 18051

Interleukin‐17A: a unique pathway in immune‐mediated diseases: psoriasis, psoriatic arthritis and rheumatoid arthritis

BW Kirkham, A Kavanaugh, K Reich - Immunology, 2014 - Wiley Online Library
… Dr Kirkham has served as a consultant and/or advisory board member and/or acted as
paid speaker and/or participated in clinical trials for the following companies: Abbott, BMS, …

The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies

DG McGonagle, IB McInnes, BW Kirkham… - Annals of the …, 2019 - ard.bmj.com
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that immune …

IL-17 in the immunopathogenesis of spondyloarthritis

…, U Srenathan, LA Burns, BW Kirkham - Nature Reviews …, 2018 - nature.com
Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes
psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic …

Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two‐year prospective study (the DAMAGE study cohort)

BW Kirkham, MN Lassere, JP Edmonds… - Arthritis & …, 2006 - Wiley Online Library
… -1β and TNFα, both at the mRNA level (weakly) in the present study and as secreted protein
in in vitro synovial membrane cultures (Kirkham BW, Juhasz KM: unpublished observations). …

Prospective evaluation of magnetic resonance imaging and physical examination findings in patients with greater trochanteric pain syndrome

…, SP Oakley, R Shnier, BW Kirkham - Arthritis & Rheumatism …, 2001 - Wiley Online Library
Objective This study examined patients with greater trochanteric pain syndrome (GTPS) to
determine the prevalence of gluteus medius pathology by utilizing magnetic resonance …

Reduction of joint inflammation and bone erosion in rat adjuvant arthritis by treatment with interleukin‐17 receptor IgG1 Fc fusion protein

…, KM Farmer, JS Walker, BW Kirkham - Arthritis & …, 2002 - Wiley Online Library
Objective To investigate the role of interleukin‐17 (IL‐17) in inflammatory arthritis by
blockade with an IL‐17 receptor/human IgG1 Fc fusion protein (muIL‐17R:Fc) in adjuvant‐induced …

[PDF][PDF] Interleukin‐17+ CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression

…, HG Evans, LS Taams, BW Kirkham - Arthritis & …, 2014 - Wiley Online Library
… Taams and Kirkham contributed equally to this work. Dr. Garood has received consulting
fees… Kirkham has received consulting fees from Novartis (less than $10,000) and speaking fees …

In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

…, C Pitzalis, GM Lord, BW Kirkham… - Proceedings of the …, 2009 - National Acad Sciences
Th17 cells are a recently defined subset of proinflammatory T cells that contribute to pathogen
clearance and tissue inflammation by means of the production of their signature cytokine IL…

Primary Sjögren's syndrome as a systemic disease: a study of participants enrolled in an international Sjögren's syndrome registry

…, Y Dong, P Helin, BW Kirkham… - Arthritis care & …, 2012 - Wiley Online Library
Objective To study the prevalence of extraglandular manifestations in primary Sjögren's
syndrome (SS) among participants enrolled in the Sjögren's International Collaborative Clinical …

Comparison of three screening tools to detect psoriatic arthritis in patients with psoriasis (CONTEST study)

…, L Kay, S Kelly, BW Kirkham… - British Journal of …, 2013 - academic.oup.com
Background Multiple questionnaires to screen for psoriatic arthritis (PsA) have been developed
but the optimal screening questionnaire is unknown. Objectives To compare three PsA …