A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation.
We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese …

5, 10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism,
has two common polymorphisms that affect enzyme activity. The objective of this study …

Objective To evaluate whether matrix metalloproteinase 3 (MMP‐3), a proteinase that is
expressed in rheumatoid synovial tissue and shows potent activity in degrading the …

Objective To develop and validate a self‐administered instrument for measuring functional
status in Japanese‐speaking rheumatoid arthritis patients. Methods We translated the …

OBJECTIVE: To clarify the mechanism of decreased serum uric acid (SUA) concentrations
during acute gouty arthritis. METHODS: Data from patients with acute gouty arthritis during …

Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for
rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti…

The evolutionary loss of hepatic urate oxidase (uricase) has resulted in humans with elevated
serum uric acid (urate). Uricase loss may have been beneficial to early primate survival. …

Objectives The prevalence of rheumatoid arthritis (RA) and its current treatment practices in
Japan are poorly documented. Therefore, we examined these factors in a Japanese health …

Recent evidence suggests that a substantial portion of complex disease risk alleles modify
gene expression in a cell-specific manner 1 , 2 , 3 , 4 . To identify candidate causal genes and …