Systemic lupus erythematosus is a multisystem autoimmune disease in which the autoantibody
response targets a variety of autoantigens of diverse subcellular location. We show here …

Objective In addition to inducing a self‐limited myopathy, statin use is associated with an
immune‐mediated necrotizing myopathy (IMNM), with autoantibodies that recognize ∼200‐kd …

Systemic autoimmune diseases are a genetically complex, heterogeneous group of disorders
in which the immune system targets a diverse but highly specific group of intracellular …

Proteolysis mediated by the interleukin 1 beta-converting enzyme (ICE) homologues is an
important mechanism of the apoptotic process. The ICE homologue apopain/CPP-32/Yama (…

The restriction of phosphatidylserine (PtdSer) to the inner surface of the plasma membrane
bilayer is lost early during apoptosis. Since PtdSer is a potent surface procoagulant, and …

BACKGROUND: Dermatomyositis (DM) is a multisystem autoimmune disease, in which
serologic evidence of immune responses to disease-specific antigenic targets is found in …

A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of
modern germ theory. Recent studies implicate mucosal surfaces as sites of disease initiation…

Statement of findings An inception cohort of 238 patients having peripheral joint synovitis of
less than 12 months duration was evaluated clinically and followed prospectively for 1 year …

Caspase-mediated proteolysis of downstream substrates is a critical element of the
execution pathway common to all forms of apoptosis studied to date. While this caspase-dependent …

Caspases are an extended family of cysteine proteases that play critical roles in apoptosis.
Animals deficient in caspases-2 or -3, which share very similar tetrapeptide cleavage …