Tumor necrosis factor α (TNFα) is a potent immunomodulator and proinflammatory cytokine
that has been implicated in the pathogenesis of autoimmune and infectious diseases. For …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs
putatively associated with rheumatoid arthritis at P = 1 × 10 −5 − 5 × 10 −7 in a genome-wide …

To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …

Objective Genetic variation in the gene for interleukin‐6 (IL‐6) contributes to the pathogenesis
of inflammatory arthritis, but the role, if any, of epigenetic variability has not been reported. …

Background/Aims: Ulcerative colitis and Crohn's disease have well-recognized familial
tendencies, but the genetic basis of this clinical observation remains unknown. The cytokine …

Epigenetics can be defined as all the meiotically and mitotically inherited changes in gene
expression that are not encoded in the DNA sequence itself. Epigenetic modifications of …

Background The NLRP3-inflammasome, implicated in the pathogenesis of several
inflammatory disorders, has been analysed in rheumatoid arthritis (RA). Methods Relative gene …

Objective. To investigate the association between frequency of alcohol consumption and
the risk and severity of RA. Methods. Frequency of alcohol consumption was recorded by …

Importance Advances have been made in identifying genetic susceptibility loci for
autoimmune diseases, but evidence is needed regarding their association with prognosis and …