Background Cancer and transplant patients with COVID-19 have a higher risk of developing
severe and even fatal respiratory diseases, especially as they may be treated with immune-…

The Study Group for Risk Factors for Rheumatoid Arthritis was established by the EULAR
Standing Committee on Investigative Rheumatology to facilitate research into the preclinical …

Complement is viewed as a critical serum-operative component of innate immunity, with
processing of its key component, C3, into activation fragments C3a and C3b confined to the …

INTRODUCTION The inflammasomes and the complement system are traditionally viewed
as quintessential components of innate immunity required for the detection and elimination of …

Rheumatoid arthritis (RA) is one of the most common chronic inflammatory syndromes. As
such, RA is often considered the prototype disease for defining both the molecular and …

Objective. Recently, 2 classes of cytokine inhibitors have been defined at the molecular level.
The largest group comprises the extracellular domains of cell surface cytokine receptors, …

Objective To investigate whether Treg cells can suppress osteoclast differentiation, and to
define a new potential link between the immune system and the skeleton. Methods Regulatory …

Background Patients on therapeutic immunosuppressants for immune-mediated inflammatory
diseases were excluded from COVID-19 vaccine trials. We therefore aimed to evaluate …

In this study we demonstrate a new form of immunoregulation: engagement on CD4 + T cells
of the complement regulator CD46 promoted the effector potential of T helper type 1 cells (T …

Although it has been widely demonstrated that human mesenchymal stem cells exert potent
immunosuppressive effects, there is little information as to whether more mature …