Natural killer (NK) cells play a key role in tumor immune surveillance. However, adoptive
immunotherapy protocols using NK cells have shown limited clinical efficacy to date, possibly …

Glomerular targets of autoimmunity in human membranous nephropathy are poorly understood.
Here, we used a combined proteomic approach to identify specific antibodies against …

Neutrophil extracellular traps (NET) formation is part of the neutrophil response to infections,
but excessive or inappropriate NETosis may trigger the production of autoantibodies and …

Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication
between the intestinal microbiota and the brain. An increasing body of preclinical and clinical …

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood, with grim
prognosis in a half of patients. Exosomes are nanometer-sized membrane vesicles derived …

Tumor chemoresistance is associated with high aerobic glycolysis rates and reduced oxidative
phosphorylation, a phenomenon called “Warburg effect” whose reversal could impair the …

Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive
functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is …

IL-27 is a member of the IL-12 family that is produced by macrophages and dendritic cells. IL-27
inhibits the growth and invasiveness of different cancers and therefore represents a …

Even if nephrotic syndrome is characterized by massive urinary loss of major plasma proteins,
a clear structural characterization based on proteomics has never been reported. Urine …

Chimeric antigen receptor (CAR) T-cell therapy has been shown to be dramatically effective
in the treatment of B-cell malignancies. However, there are still substantial obstacles to …